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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for <t>TLR9</t> stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for <t>TLR9</t> stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for <t>TLR9</t> stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for <t>TLR9</t> stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for <t>TLR9</t> stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for <t>TLR9</t> stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for <t>TLR9</t> stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.
Tlr9 Agonist, supplied by InvivoGen, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tlr9 agonist/product/InvivoGen
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tlr9 agonist - by Bioz Stars, 2026-02
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a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for TLR9 stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.

Journal: bioRxiv

Article Title: Cancer pathway connectivity resolved by drug perturbation and RNA sequencing

doi: 10.64898/2025.12.11.692401

Figure Lengend Snippet: a , Dose-response curves of 20 patients treated with IRAK4 inhibitor and IRAK4 inhibitor combined with 1 µg/mL CpG-ODN for TLR9 stimulation. b , Gene expression of genes on the amplified locus chr12:42,538,673-chr12: 44,229,999 (hg19) by trisomy 12 status for the CLL cohort (n = 210) from Lütge et al. . Significance levels were calculated using two-tailed Student’s t -test and shown as nominal P -values.

Article Snippet: For the CpG stimulation, cells were supplemented with 1.25 μg/mL of the TLR9 agonist ODN2006 (InvivoGen) before seeding to reach a final assay concentration of 1 μg/mL.

Techniques: Gene Expression, Amplification, Two Tailed Test