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The effect of tested DCF and IBU samples before and after treatment with Cunninghamella on the viability of HepG2 ( a , e ), SH-SY5Y ( b , f ), <t>astrocytes</t> ( c , g ), and H9c2 ( d , h ) cells. Graphs represent the number of viable cells expressed as percent of control ± SD (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).
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The effect of tested DCF and IBU samples before and after treatment with Cunninghamella on the viability of HepG2 ( a , e ), SH-SY5Y ( b , f ), astrocytes ( c , g ), and H9c2 ( d , h ) cells. Graphs represent the number of viable cells expressed as percent of control ± SD (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

Journal: Scientific Reports

Article Title: Biotransformation of common NSAIDs by Cunninghamella species and resulting metabolite toxicity

doi: 10.1038/s41598-026-58519-6

Figure Lengend Snippet: The effect of tested DCF and IBU samples before and after treatment with Cunninghamella on the viability of HepG2 ( a , e ), SH-SY5Y ( b , f ), astrocytes ( c , g ), and H9c2 ( d , h ) cells. Graphs represent the number of viable cells expressed as percent of control ± SD (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).

Article Snippet: Human hepatocellular carcinoma HepG2 (ATCC HB-8065; ATCC, Manassas, VA, USA), human neuroblastoma SH-SY5Y (CRL-2266; ATCC), immortalized human astrocytes ( P10251 -IM; Innoprot, Spain), and rat cardiomyocytes H9c2 (CRL-1446; ATCC) cell lines were cultured in media recommended by the manufacturers.

Techniques: Control