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(a-d) Treatment with <t>pomalidomide</t> alone did not change monocyte TLR and CD 14 but revert the GM-CSF-induced downregulation of TLR1 (a), TLR2 (b), TLR4 (c) and CD14 (d). (e and f) Cytokine staining on single cell level by flow cytometry shows that presence of GM-CSF (dark grey histograms) inhibited TNF-α cytokine production in CD14 + monocytes upon LPS (e) or LTA (f) stimulation. Additional administration of pomalidomide prior to GM-CSF partly reverted the GM-CSF-induced dampening of proinflammatory cytokine production after LPS or LTA challenge (open black histograms). Shaded histograms show robust TNF-α production in monocytes stimulated with LTA or LPS alone. Histograms shown are from three individually performed experiments.
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(a-d) Treatment with <t>pomalidomide</t> alone did not change monocyte TLR and CD 14 but revert the GM-CSF-induced downregulation of TLR1 (a), TLR2 (b), TLR4 (c) and CD14 (d). (e and f) Cytokine staining on single cell level by flow cytometry shows that presence of GM-CSF (dark grey histograms) inhibited TNF-α cytokine production in CD14 + monocytes upon LPS (e) or LTA (f) stimulation. Additional administration of pomalidomide prior to GM-CSF partly reverted the GM-CSF-induced dampening of proinflammatory cytokine production after LPS or LTA challenge (open black histograms). Shaded histograms show robust TNF-α production in monocytes stimulated with LTA or LPS alone. Histograms shown are from three individually performed experiments.
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(a-d) Treatment with <t>pomalidomide</t> alone did not change monocyte TLR and CD 14 but revert the GM-CSF-induced downregulation of TLR1 (a), TLR2 (b), TLR4 (c) and CD14 (d). (e and f) Cytokine staining on single cell level by flow cytometry shows that presence of GM-CSF (dark grey histograms) inhibited TNF-α cytokine production in CD14 + monocytes upon LPS (e) or LTA (f) stimulation. Additional administration of pomalidomide prior to GM-CSF partly reverted the GM-CSF-induced dampening of proinflammatory cytokine production after LPS or LTA challenge (open black histograms). Shaded histograms show robust TNF-α production in monocytes stimulated with LTA or LPS alone. Histograms shown are from three individually performed experiments.
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(a-d) Treatment with pomalidomide alone did not change monocyte TLR and CD 14 but revert the GM-CSF-induced downregulation of TLR1 (a), TLR2 (b), TLR4 (c) and CD14 (d). (e and f) Cytokine staining on single cell level by flow cytometry shows that presence of GM-CSF (dark grey histograms) inhibited TNF-α cytokine production in CD14 + monocytes upon LPS (e) or LTA (f) stimulation. Additional administration of pomalidomide prior to GM-CSF partly reverted the GM-CSF-induced dampening of proinflammatory cytokine production after LPS or LTA challenge (open black histograms). Shaded histograms show robust TNF-α production in monocytes stimulated with LTA or LPS alone. Histograms shown are from three individually performed experiments.

Journal: PLoS ONE

Article Title: GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes

doi: 10.1371/journal.pone.0162667

Figure Lengend Snippet: (a-d) Treatment with pomalidomide alone did not change monocyte TLR and CD 14 but revert the GM-CSF-induced downregulation of TLR1 (a), TLR2 (b), TLR4 (c) and CD14 (d). (e and f) Cytokine staining on single cell level by flow cytometry shows that presence of GM-CSF (dark grey histograms) inhibited TNF-α cytokine production in CD14 + monocytes upon LPS (e) or LTA (f) stimulation. Additional administration of pomalidomide prior to GM-CSF partly reverted the GM-CSF-induced dampening of proinflammatory cytokine production after LPS or LTA challenge (open black histograms). Shaded histograms show robust TNF-α production in monocytes stimulated with LTA or LPS alone. Histograms shown are from three individually performed experiments.

Article Snippet: The thalidomide analogue pomalidomide (CC-4047) was kindly provided by Celgene (Summit, NJ) and a stock solution of 20 mM was dissolved in DMSO.

Techniques: Staining, Flow Cytometry