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Schematic representation of the TETNPs@Gel in-situ vaccination platform , achieving sustained and potent anti-cancer immune responses through the controlled-release mechanism of TETNPs and HA-DOPA/Mn hydrogels. In-situ gel vaccine encapsulating <t>tetrandrine</t> nanoparticles forms a local reservoir for controlled sustained release of immunotherapeutic agents. This vaccine effectively triggers tumor vascular normalization, activates dendritic cells and effector CD8 + T cells within tumor tissue, thereby inhibiting progression and preventing recurrence in immunologically cold tumors
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Schematic representation of the TETNPs@Gel in-situ vaccination platform , achieving sustained and potent anti-cancer immune responses through the controlled-release mechanism of TETNPs and HA-DOPA/Mn hydrogels. In-situ gel vaccine encapsulating <t>tetrandrine</t> nanoparticles forms a local reservoir for controlled sustained release of immunotherapeutic agents. This vaccine effectively triggers tumor vascular normalization, activates dendritic cells and effector CD8 + T cells within tumor tissue, thereby inhibiting progression and preventing recurrence in immunologically cold tumors
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Schematic representation of the TETNPs@Gel in-situ vaccination platform , achieving sustained and potent anti-cancer immune responses through the controlled-release mechanism of TETNPs and HA-DOPA/Mn hydrogels. In-situ gel vaccine encapsulating <t>tetrandrine</t> nanoparticles forms a local reservoir for controlled sustained release of immunotherapeutic agents. This vaccine effectively triggers tumor vascular normalization, activates dendritic cells and effector CD8 + T cells within tumor tissue, thereby inhibiting progression and preventing recurrence in immunologically cold tumors
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Schematic representation of the TETNPs@Gel in-situ vaccination platform , achieving sustained and potent anti-cancer immune responses through the controlled-release mechanism of TETNPs and HA-DOPA/Mn hydrogels. In-situ gel vaccine encapsulating <t>tetrandrine</t> nanoparticles forms a local reservoir for controlled sustained release of immunotherapeutic agents. This vaccine effectively triggers tumor vascular normalization, activates dendritic cells and effector CD8 + T cells within tumor tissue, thereby inhibiting progression and preventing recurrence in immunologically cold tumors
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Schematic representation of the TETNPs@Gel in-situ vaccination platform , achieving sustained and potent anti-cancer immune responses through the controlled-release mechanism of TETNPs and HA-DOPA/Mn hydrogels. In-situ gel vaccine encapsulating <t>tetrandrine</t> nanoparticles forms a local reservoir for controlled sustained release of immunotherapeutic agents. This vaccine effectively triggers tumor vascular normalization, activates dendritic cells and effector CD8 + T cells within tumor tissue, thereby inhibiting progression and preventing recurrence in immunologically cold tumors
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Schematic representation of the TETNPs@Gel in-situ vaccination platform , achieving sustained and potent anti-cancer immune responses through the controlled-release mechanism of TETNPs and HA-DOPA/Mn hydrogels. In-situ gel vaccine encapsulating tetrandrine nanoparticles forms a local reservoir for controlled sustained release of immunotherapeutic agents. This vaccine effectively triggers tumor vascular normalization, activates dendritic cells and effector CD8 + T cells within tumor tissue, thereby inhibiting progression and preventing recurrence in immunologically cold tumors

Journal: Journal of Nanobiotechnology

Article Title: Tetrandrine-based in situ vaccination via multifunctional Mn²⁺-hyaluronic acid hydrogel loading gelatinase-responsive nanoparticles

doi: 10.1186/s12951-026-04545-5

Figure Lengend Snippet: Schematic representation of the TETNPs@Gel in-situ vaccination platform , achieving sustained and potent anti-cancer immune responses through the controlled-release mechanism of TETNPs and HA-DOPA/Mn hydrogels. In-situ gel vaccine encapsulating tetrandrine nanoparticles forms a local reservoir for controlled sustained release of immunotherapeutic agents. This vaccine effectively triggers tumor vascular normalization, activates dendritic cells and effector CD8 + T cells within tumor tissue, thereby inhibiting progression and preventing recurrence in immunologically cold tumors

Article Snippet: Tetrandrine (TET) reagents were purchased from MCE (Shanghai, China).

Techniques: In Situ