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Overlap between the SVR-VLSM result for nonword error rate and the SVR-VLSM result that was found to reduce high imageability word reading, relative to low imageability word reading, in Staples et al.

Journal: bioRxiv

Article Title: Meaning for reading pseudowords: errors reveal semantic influences on pseudoword reading after stroke

doi: 10.64898/2026.05.13.724881

Figure Lengend Snippet: Overlap between the SVR-VLSM result for nonword error rate and the SVR-VLSM result that was found to reduce high imageability word reading, relative to low imageability word reading, in Staples et al.

Article Snippet: Overlaying the SVR-VLSM map for NE errors with the results of Staples et al., 2025 demonstrated highly overlapping lesion maps, with lesions in the STS and STG producing both semantic reading deficits as evidenced by a reduced imageability effect and also high rates of NE in pseudoword reading ( ).

Techniques:

(A) Light purple shading indicates voxels excluded from the SVR-VLSM analysis due to insufficient lesion coverage (<8). Color spectrum shading indicates voxels considered in the SVR-VLSM analysis. (B) SVR-VLSM analyses show that reduced pseudoword reading accuracy (blue) was associated with lesions to the posterior superior temporal gyrus and the supramarginal gyrus (clusterwise p=.009). Greater lexicalization error rate (purple) was associated with lesions to the left frontal white matter and anterior putamen (clusterwise p =0.043). Greater nonword error rate (red) was associated with lesions to the posterior superior temporal gyrus and sulcus (clusterwise p =0.002). Lesions associated with both nonword errors and pseudoword reading accuracy (yellow) were associated with the planum temporale and deep temporal white matter. There was no overlap between the lesions associated with lexicalization errors and either nonword errors or reading accuracy. Error rate analyses control for the alternate error rate, age, education, lesion volume, log-transformed chronicity in months, and Apraxia of Speech Rating Scale Apraxia Severity score.

Journal: bioRxiv

Article Title: Meaning for reading pseudowords: errors reveal semantic influences on pseudoword reading after stroke

doi: 10.64898/2026.05.13.724881

Figure Lengend Snippet: (A) Light purple shading indicates voxels excluded from the SVR-VLSM analysis due to insufficient lesion coverage (<8). Color spectrum shading indicates voxels considered in the SVR-VLSM analysis. (B) SVR-VLSM analyses show that reduced pseudoword reading accuracy (blue) was associated with lesions to the posterior superior temporal gyrus and the supramarginal gyrus (clusterwise p=.009). Greater lexicalization error rate (purple) was associated with lesions to the left frontal white matter and anterior putamen (clusterwise p =0.043). Greater nonword error rate (red) was associated with lesions to the posterior superior temporal gyrus and sulcus (clusterwise p =0.002). Lesions associated with both nonword errors and pseudoword reading accuracy (yellow) were associated with the planum temporale and deep temporal white matter. There was no overlap between the lesions associated with lexicalization errors and either nonword errors or reading accuracy. Error rate analyses control for the alternate error rate, age, education, lesion volume, log-transformed chronicity in months, and Apraxia of Speech Rating Scale Apraxia Severity score.

Article Snippet: Overlaying the SVR-VLSM map for NE errors with the results of Staples et al., 2025 demonstrated highly overlapping lesion maps, with lesions in the STS and STG producing both semantic reading deficits as evidenced by a reduced imageability effect and also high rates of NE in pseudoword reading ( ).

Techniques: Control, Transformation Assay

Journal: bioRxiv

Article Title: Meaning for reading pseudowords: errors reveal semantic influences on pseudoword reading after stroke

doi: 10.64898/2026.05.13.724881

Figure Lengend Snippet:

Article Snippet: Overlaying the SVR-VLSM map for NE errors with the results of Staples et al., 2025 demonstrated highly overlapping lesion maps, with lesions in the STS and STG producing both semantic reading deficits as evidenced by a reduced imageability effect and also high rates of NE in pseudoword reading ( ).

Techniques: