Journal: Journal of Zhejiang University-SCIENCE B

Article Title: OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information

doi: 10.1631/jzus.b2100512

Figure Lengend Snippet: Fig. 1 Architecture diagram of the development process of OShnscc. OShnscc: Online consensus Survival tool for Head and Neck Squamous Cell Carcinoma; TCGA: The Cancer Genome Atlas; HNSCC: head and neck squamous cell carcinoma; KM: Kaplan-Meier.

Article Snippet: Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 2022 23(3):249-257 www.jzus.zju.edu.cn; www.springer.com/journal/11585 E-mail: jzus_b@zju.edu.cn OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information Guosen ZHANG1, Qiang WANG2, Xinlei QI1, Huimin YANG1, Xiaodong SU1, Manman YANG1, Chao JIANG1, Yang AN1, Hong ZHENG1, Lu ZHANG1, Wan ZHU3, Jiancheng GUO4,5,6*, Xiangqian GUO1* 1Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China 2School of Software, Henan University, Kaifeng 475004, China 3Department of Anesthesia, Stanford University, Stanford, CA 94305, USA 4Department of Molecular Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 5Precision Medicine Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China 6Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90%) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx.

Techniques:

Journal: Journal of Zhejiang University-SCIENCE B

Article Title: OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information

doi: 10.1631/jzus.b2100512

Figure Lengend Snippet: Fig. 2 Survival analysis by clinical factors for all datasets in OShnscc. (a) TNM stage; (b) Grade; (c) Age; (d) Gender; (e) Race; (f) Tumor subsite. OShnscc: Online consensus Survival tool for Head and Neck Squamous Cell Carcinoma; TNM: tumor node metastasis.

Article Snippet: Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 2022 23(3):249-257 www.jzus.zju.edu.cn; www.springer.com/journal/11585 E-mail: jzus_b@zju.edu.cn OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information Guosen ZHANG1, Qiang WANG2, Xinlei QI1, Huimin YANG1, Xiaodong SU1, Manman YANG1, Chao JIANG1, Yang AN1, Hong ZHENG1, Lu ZHANG1, Wan ZHU3, Jiancheng GUO4,5,6*, Xiangqian GUO1* 1Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China 2School of Software, Henan University, Kaifeng 475004, China 3Department of Anesthesia, Stanford University, Stanford, CA 94305, USA 4Department of Molecular Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 5Precision Medicine Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China 6Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90%) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx.

Techniques:

Journal: Journal of Zhejiang University-SCIENCE B

Article Title: OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information

doi: 10.1631/jzus.b2100512

Figure Lengend Snippet: Fig. 4 Kaplan-Meier curve based on TMED4 expression in OShnscc using default parameters of “TCGA” as data source, “OS” for survival, and “Upper 25%” for patients splitting. TMED4: transmembrane p24 trafficking protein 4 gene; OShnscc: Online consensus Survival tool for Head and Neck Squamous Cell Carcinoma; TCGA: The Cancer Genome Atlas; HNSCC: head and neck squamous cell carcinoma; TNM: tumor node metastasis; mRNA: messenger RNA; HR: hazard ratio; CI: confidence interval; OS: overall survival; HPV: human papilloma virus; DFI: disease-free interval; PFI: progression-free interval.

Article Snippet: Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 2022 23(3):249-257 www.jzus.zju.edu.cn; www.springer.com/journal/11585 E-mail: jzus_b@zju.edu.cn OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information Guosen ZHANG1, Qiang WANG2, Xinlei QI1, Huimin YANG1, Xiaodong SU1, Manman YANG1, Chao JIANG1, Yang AN1, Hong ZHENG1, Lu ZHANG1, Wan ZHU3, Jiancheng GUO4,5,6*, Xiangqian GUO1* 1Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China 2School of Software, Henan University, Kaifeng 475004, China 3Department of Anesthesia, Stanford University, Stanford, CA 94305, USA 4Department of Molecular Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 5Precision Medicine Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China 6Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90%) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx.

Techniques: Expressing, Virus

Journal: Journal of Zhejiang University-SCIENCE B

Article Title: OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information

doi: 10.1631/jzus.b2100512

Figure Lengend Snippet: Fig. 5 Options of main input parameters and clinical factors provided in OShnscc. (a) Survival term; (b) Split patients by; (c) TNM stage; (d) Grade; (e) Gender; (f) Lymph invasion; (g) Race; (h) Alcohol; (i) Smoking; (j) Tumor subsite; (k) HPV status. OShnscc: Online consensus Survival tool for Head and Neck Squamous Cell Carcinoma; TNM: tumor node metastasis; HPV: human papilloma virus.

Article Snippet: Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 2022 23(3):249-257 www.jzus.zju.edu.cn; www.springer.com/journal/11585 E-mail: jzus_b@zju.edu.cn OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information Guosen ZHANG1, Qiang WANG2, Xinlei QI1, Huimin YANG1, Xiaodong SU1, Manman YANG1, Chao JIANG1, Yang AN1, Hong ZHENG1, Lu ZHANG1, Wan ZHU3, Jiancheng GUO4,5,6*, Xiangqian GUO1* 1Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China 2School of Software, Henan University, Kaifeng 475004, China 3Department of Anesthesia, Stanford University, Stanford, CA 94305, USA 4Department of Molecular Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 5Precision Medicine Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China 6Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90%) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx.

Techniques: Virus

Journal: Journal of Zhejiang University-SCIENCE B

Article Title: OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information

doi: 10.1631/jzus.b2100512

Figure Lengend Snippet: Fig. 6 Survival analysis of IL11 gene in OShnscc. (a‒e) Kaplan-Meier survival curves of IL11 with OS in the data source of TCGA (a), GSE31056 (b), GSE3292 (c), GSE65858 (d), GSE41613 (e); (f) Forest plots for the meta-analysis of the prognostic values of IL11 gene for OS analysis in OShnscc. IL11: interleukin 11; OShnscc: Online consensus Survival tool for Head and Neck Squamous Cell Carcinoma; TCGA: The Cancer Genome Atlas; OS: overall survival; HR: hazard ratio; CI: confidence interval; mRNA: messenger RNA.

Article Snippet: Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) 2022 23(3):249-257 www.jzus.zju.edu.cn; www.springer.com/journal/11585 E-mail: jzus_b@zju.edu.cn OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information Guosen ZHANG1, Qiang WANG2, Xinlei QI1, Huimin YANG1, Xiaodong SU1, Manman YANG1, Chao JIANG1, Yang AN1, Hong ZHENG1, Lu ZHANG1, Wan ZHU3, Jiancheng GUO4,5,6*, Xiangqian GUO1* 1Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China 2School of Software, Henan University, Kaifeng 475004, China 3Department of Anesthesia, Stanford University, Stanford, CA 94305, USA 4Department of Molecular Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 5Precision Medicine Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China 6Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90%) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx.

Techniques: