Journal: Blood Cancer Journal

Article Title: Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment

doi: 10.1038/s41408-022-00773-8

Figure Lengend Snippet: Summary of major studies associating L-CH with lymphoid malignancy.

Article Snippet: Niroula et al. (2021) , Detection of SNVs/indels in WES data at 56 M-CH related genes and 235 genes recurrently mutated in lymphoid malignancy (VAF > 2%). mCAs were previously detected in a prior study. CH and mCAs were excluded if they were detected less than 6 months before a hematologic malignancy diagnosis. , 420,969 individuals with SNP microarray data and 55,383 individuals with WES from the UK Biobank and Mass General Brigham Biobank , CHIP occurs at both M-CHIP/M-mCA and L-CHIP/L-mCA loci and increases with age. M-CH and L-CH loci clearly segregate on the incidence myeloid and lymphoid malignancy. M-CHIP is dominated by DNMT3A, TET2, and ASXL1 somatic mutants, while L-CHIP is spread more evenly across a large number of genes. CLL was the dominant lymphoid malignancy occurring subsequent to L-CH. , [ ] .

Techniques: Genome Wide, Sequencing, Mutagenesis, Clone Assay, Biomarker Discovery, Microarray, DNA Sequencing, Clinical Proteomics