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WholeGenome LLC
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Signature Genomic Laboratories LLC
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Signature Genomic Laboratories LLC
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Signature Genomic Laboratories LLC
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Journal: Clinical Case Reports
Article Title: Prenatal diagnosis of complex rearrangement of chromosome 21: The significance of interphase and metaphase fluorescence in situ hybridization and comparative genomic hybridization
doi: 10.1002/ccr3.22
Figure Lengend Snippet: Microarray characterization of a complex rearrangement of chromosome 21. Microarray plot showing (1) a two-copy gain of 25 oligonucleotide probes from the long arm of chromosome 21 at 21q11.2, ˜220 kb in size; immediately followed by (2) a single-copy gain of 285 oligonucleotide probes from 21q11.2-21q21.1, ˜2.74 Mb in size; immediately followed by (3) a two-copy gain of 85 oligonucleotide probes from 21q21.1, ˜860 kb in size. Also present are (4) a single-copy gain of 107 oligonucleotide probes from 21q21.1, ˜1.35 Mb in size; (5) a single-copy loss of 153 oligonucleotide probes from 21q21.3q-21q22.11, ˜3.77 Mb in size; (6) a single-copy gain of 483 oligonucleotide probes from 21q22.12.-21q22.2, ˜5.21 Mb in size; and (7) a single-copy gain of 528 oligonucleotide probes from terminal 21q22.2-21q22.3, ˜5.89 Mb in size. Probes are ordered on the x -axis according to physical mapping positions, with the most proximal q-arm probes to the left and the most distal q-arm probes to the right. Values along the y -axis represent log2 ratios of patient:control signal intensities. Results are visualized using Genoglyphix® (Signature Genomics, Spokane WA).
Article Snippet: The analysis of aCGH of the umbilical cord specimen, using a
Techniques: Microarray, Control