Journal: BMC Oral Health

Article Title: Targeting CGRP signaling alleviates cancer-associated pain in oral squamous cell carcinoma

doi: 10.1186/s12903-026-08444-x

Figure Lengend Snippet: Analgesic effects of Rimegepant in OSCC-associated pain demonstrated via the unilateral tongue orthotopic transplantation model. A Construction of the unilateral tongue orthotopic transplantation model and drug injection with mechanical threshold measurement protocol. B Following tumor transplantation, the differences in mechanical sensitivity between the transplanted ( n = 14) and non-transplanted ( n = 10) sides were compared using unpaired two-tailed Student’s t test. C Changes in sensitivity 1 h after Rimegepant (50 mg/kg), Rimegepant (10 mg/kg) and Carprofen treatment were performed using one-way ANOVA. Each dataset included results from monitoring over 4 consecutive days ( n = 6–8/group). D Changes in sensitivity following Rimegepant (50 mg/kg) and Tramadol treatment at 1 h were performed using one-way ANOVA. Each dataset included results from monitoring over 4 consecutive days ( n = 6–8/group). E The 4-day trends of facial mechanical sensitivities 24 h after Rimegepant (50 mg/kg) and Tramadol treatment. ( n = 6–8/group). F Changes in sensitivity 1 h after Tramadol, Carprofen treatment and local lingual injection of Rimegepant (10 mg/kg) in CAL27 and SCC25 xenograft models were performed using one-way ANOVA( n = 8). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, ns P > 0.05

Article Snippet: Human OSCC CAL27 and SCC25 cells were purchased from the American Type Culture Collection (USA).

Techniques: Transplantation Assay, Injection, Two Tailed Test