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Sirius Fine Chemicals SiChem GmbH synthesises active substances for the early phase/toxicology of drug development, mainly for the pharmaceutical industry. Our special focus is on prodrugs, i.e. the active ingredient is initially inactive and is only released IN the organism. This can be done, for example, by endogenous enzymes. A new approach is the release of the API (Active Pharmaceutical Ingredient) through a click reaction: here, the clickable inactive API is first transported to the site of action (e.g. to the tumour), where it reacts with a previously injected antibody or biopolymer that is also clickable. We are one of the leading providers for inositol phosphates as well as a large variety of membranepermeant and photoactivatable derivatives. Our portfolio has been supplemented by clickable unnatural amino acids and other useful tools for Click-Chemistry.