Review





Similar Products

recombinant human md 2 rhmd 2 protein  (R&D Systems)
94
R&D Systems recombinant human md 2 rhmd 2 protein
FIGURE 6 Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway. LPS binding <t>to</t> <t>MD2</t> promotes the dimerization of TLR4/MD‐2. The conformational changes in the TLR4 induce the recruitment of intracellular adaptor proteins to activate the downstream signalling pathway. The MyD88‐dependent pathway involves activation of MAPK cascades and IKK (IκB kinase). Phosphorylation of IKKs leads to degradation of IκBα and the release of NF‐κB. Transcription factors such as NF‐κB, AP‐1 and etc. participate in driving gene expression of proinflammatory cytokines. The activated PI3K/Akt in the downstream of TLR4 induces nuclear translation of NF‐κB. 25HC could directly interact with MD2 to prevent LPS‐induced activation of Akt and NF‐κB signal pathway
Recombinant Human Md 2 Rhmd 2 Protein, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant human md 2 rhmd 2 protein/product/R&D Systems
Average 94 stars, based on 1 article reviews
recombinant human md 2 rhmd 2 protein - by Bioz Stars, 2026-06
94/100 stars
  Buy from Supplier
rhmd 2  (R&D Systems)
94
R&D Systems rhmd 2
FIGURE 6 Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway. LPS binding <t>to</t> <t>MD2</t> promotes the dimerization of TLR4/MD‐2. The conformational changes in the TLR4 induce the recruitment of intracellular adaptor proteins to activate the downstream signalling pathway. The MyD88‐dependent pathway involves activation of MAPK cascades and IKK (IκB kinase). Phosphorylation of IKKs leads to degradation of IκBα and the release of NF‐κB. Transcription factors such as NF‐κB, AP‐1 and etc. participate in driving gene expression of proinflammatory cytokines. The activated PI3K/Akt in the downstream of TLR4 induces nuclear translation of NF‐κB. 25HC could directly interact with MD2 to prevent LPS‐induced activation of Akt and NF‐κB signal pathway
Rhmd 2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rhmd 2/product/R&D Systems
Average 94 stars, based on 1 article reviews
rhmd 2 - by Bioz Stars, 2026-06
94/100 stars
  Buy from Supplier
recombinant human md-2 (rhmd-2, or rhmd-2 mutant) proteins  (Biowit Technologies)
90
Biowit Technologies recombinant human md-2 (rhmd-2, or rhmd-2 mutant) proteins
FIGURE 6 Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway. LPS binding <t>to</t> <t>MD2</t> promotes the dimerization of TLR4/MD‐2. The conformational changes in the TLR4 induce the recruitment of intracellular adaptor proteins to activate the downstream signalling pathway. The MyD88‐dependent pathway involves activation of MAPK cascades and IKK (IκB kinase). Phosphorylation of IKKs leads to degradation of IκBα and the release of NF‐κB. Transcription factors such as NF‐κB, AP‐1 and etc. participate in driving gene expression of proinflammatory cytokines. The activated PI3K/Akt in the downstream of TLR4 induces nuclear translation of NF‐κB. 25HC could directly interact with MD2 to prevent LPS‐induced activation of Akt and NF‐κB signal pathway
Recombinant Human Md 2 (Rhmd 2, Or Rhmd 2 Mutant) Proteins, supplied by Biowit Technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant human md-2 (rhmd-2, or rhmd-2 mutant) proteins/product/Biowit Technologies
Average 90 stars, based on 1 article reviews
recombinant human md-2 (rhmd-2, or rhmd-2 mutant) proteins - by Bioz Stars, 2026-06
90/100 stars
  Buy from Supplier
human rhmd 2 fusion protein  (R&D Systems)
94
R&D Systems human rhmd 2 fusion protein
FIGURE 6 Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway. LPS binding <t>to</t> <t>MD2</t> promotes the dimerization of TLR4/MD‐2. The conformational changes in the TLR4 induce the recruitment of intracellular adaptor proteins to activate the downstream signalling pathway. The MyD88‐dependent pathway involves activation of MAPK cascades and IKK (IκB kinase). Phosphorylation of IKKs leads to degradation of IκBα and the release of NF‐κB. Transcription factors such as NF‐κB, AP‐1 and etc. participate in driving gene expression of proinflammatory cytokines. The activated PI3K/Akt in the downstream of TLR4 induces nuclear translation of NF‐κB. 25HC could directly interact with MD2 to prevent LPS‐induced activation of Akt and NF‐κB signal pathway
Human Rhmd 2 Fusion Protein, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human rhmd 2 fusion protein/product/R&D Systems
Average 94 stars, based on 1 article reviews
human rhmd 2 fusion protein - by Bioz Stars, 2026-06
94/100 stars
  Buy from Supplier
rhmd-2  (Biowit Technologies)
90
Biowit Technologies rhmd-2
FIGURE 6 Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway. LPS binding <t>to</t> <t>MD2</t> promotes the dimerization of TLR4/MD‐2. The conformational changes in the TLR4 induce the recruitment of intracellular adaptor proteins to activate the downstream signalling pathway. The MyD88‐dependent pathway involves activation of MAPK cascades and IKK (IκB kinase). Phosphorylation of IKKs leads to degradation of IκBα and the release of NF‐κB. Transcription factors such as NF‐κB, AP‐1 and etc. participate in driving gene expression of proinflammatory cytokines. The activated PI3K/Akt in the downstream of TLR4 induces nuclear translation of NF‐κB. 25HC could directly interact with MD2 to prevent LPS‐induced activation of Akt and NF‐κB signal pathway
Rhmd 2, supplied by Biowit Technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rhmd-2/product/Biowit Technologies
Average 90 stars, based on 1 article reviews
rhmd-2 - by Bioz Stars, 2026-06
90/100 stars
  Buy from Supplier

Image Search Results


FIGURE 6 Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway. LPS binding to MD2 promotes the dimerization of TLR4/MD‐2. The conformational changes in the TLR4 induce the recruitment of intracellular adaptor proteins to activate the downstream signalling pathway. The MyD88‐dependent pathway involves activation of MAPK cascades and IKK (IκB kinase). Phosphorylation of IKKs leads to degradation of IκBα and the release of NF‐κB. Transcription factors such as NF‐κB, AP‐1 and etc. participate in driving gene expression of proinflammatory cytokines. The activated PI3K/Akt in the downstream of TLR4 induces nuclear translation of NF‐κB. 25HC could directly interact with MD2 to prevent LPS‐induced activation of Akt and NF‐κB signal pathway

Journal: Journal of cellular and molecular medicine

Article Title: 25-Hydroxycholesterol protects against acute lung injury via targeting MD-2.

doi: 10.1111/jcmm.13820

Figure Lengend Snippet: FIGURE 6 Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway. LPS binding to MD2 promotes the dimerization of TLR4/MD‐2. The conformational changes in the TLR4 induce the recruitment of intracellular adaptor proteins to activate the downstream signalling pathway. The MyD88‐dependent pathway involves activation of MAPK cascades and IKK (IκB kinase). Phosphorylation of IKKs leads to degradation of IκBα and the release of NF‐κB. Transcription factors such as NF‐κB, AP‐1 and etc. participate in driving gene expression of proinflammatory cytokines. The activated PI3K/Akt in the downstream of TLR4 induces nuclear translation of NF‐κB. 25HC could directly interact with MD2 to prevent LPS‐induced activation of Akt and NF‐κB signal pathway

Article Snippet: Recombinant human MD‐2 (rhMD‐2) protein was obtained from R&D Systems (Minneapolis, MN, USA).

Techniques: Binding Assay, Activation Assay, Phospho-proteomics, Gene Expression