Journal: Frontiers in Oncology

Article Title: Immunotherapy combined with rh-endostatin improved clinical outcomes over immunotherapy plus chemotherapy for second-line treatment of advanced NSCLC

doi: 10.3389/fonc.2023.1137224

Figure Lengend Snippet: Comparison of similar clinical studies.

Article Snippet: Patients classified as members of the IE group received rh-endostatin (Endostar, Shandong Simcere-Medgenn Bio-pharmaceutical Co., Ltd.) at 210 mg CIV for 168 hours using an infusion pump, whereas those receiving chemotherapy were categorized as members of the IC group.

Techniques:

Journal: Cancer Management and Research

Article Title: Antitumor effects of Endostar(rh-endostatin) combined with gemcitabine in different administration sequences to treat Lewis lung carcinoma

doi: 10.2147/CMAR.S192868

Figure Lengend Snippet: Treatment schedule. Abbreviations: Ip, intraperitoneal; ES, endostar; GEM, gemcitabine.

Article Snippet: The human recombinant endostatin, Endostar (rh-ES), was kindly provided by Shandong Simcere Medgenn Biopharmaceutical Co. (Yantai, Shandong, China) and stored at 4 °C.

Techniques:

Journal: Cancer Management and Research

Article Title: Antitumor effects of Endostar(rh-endostatin) combined with gemcitabine in different administration sequences to treat Lewis lung carcinoma

doi: 10.2147/CMAR.S192868

Figure Lengend Snippet: Tumor size, tumor weight and tumor samples of various treatment regimens. ( A ) Suppression of tumor growth after different treatment regimens in C57/BL6 mice xenografted with LLC. ( B ) Mean tumor weights of mice from different treatment regimens. ( C ) Tumor samples of mice from different treatment regimens. * P <0.05 vs control group, ** P <0.05 vs all groups. Abbreviations: Ip, intraperitoneal; ES, endostar; GEM, gemcitabine; LLC, Lewis lung carcinoma.

Article Snippet: The human recombinant endostatin, Endostar (rh-ES), was kindly provided by Shandong Simcere Medgenn Biopharmaceutical Co. (Yantai, Shandong, China) and stored at 4 °C.

Techniques: Control

Journal: Cancer Management and Research

Article Title: Antitumor effects of Endostar(rh-endostatin) combined with gemcitabine in different administration sequences to treat Lewis lung carcinoma

doi: 10.2147/CMAR.S192868

Figure Lengend Snippet: Micro 18F-FDG PET/CT imaging. ( A ) Representative 18F-FDG PET scans of mice one day after treatment with various regimens. ( B ) SUVmax associated with various treatment regimens. * P <0.05 vs control group, ** P <0.05 vs all groups. Abbreviations: ES, endostar; GEM, gemcitabine.

Article Snippet: The human recombinant endostatin, Endostar (rh-ES), was kindly provided by Shandong Simcere Medgenn Biopharmaceutical Co. (Yantai, Shandong, China) and stored at 4 °C.

Techniques: Positron Emission Tomography-Computed Tomography, Imaging, Control

Journal: Cancer Management and Research

Article Title: Antitumor effects of Endostar(rh-endostatin) combined with gemcitabine in different administration sequences to treat Lewis lung carcinoma

doi: 10.2147/CMAR.S192868

Figure Lengend Snippet: Cell cycle analysis of tumor tissue from mice in different groups. ( A ) Flow cytometry analysis of cell cycle redistribution in xenografts from mice in different groups. ( B ) Percentage of cells in G0/G1, S, G2/M phase in mouse xenografts in different treatment groups. * P <0.05 vs control group, ** P <0.05 vs all groups. Abbreviations: ES, endostar; GEM, gemcitabine.

Article Snippet: The human recombinant endostatin, Endostar (rh-ES), was kindly provided by Shandong Simcere Medgenn Biopharmaceutical Co. (Yantai, Shandong, China) and stored at 4 °C.

Techniques: Cell Cycle Assay, Flow Cytometry, Control

Journal: Cancer Management and Research

Article Title: Antitumor effects of Endostar(rh-endostatin) combined with gemcitabine in different administration sequences to treat Lewis lung carcinoma

doi: 10.2147/CMAR.S192868

Figure Lengend Snippet: Expression of VEGF in Lewis tumor tissue. ( A ) Immunohistochemical staining against VEGF of xenografted Lewis treated tissues under various treatment regimens (×400 magnification). (B) VEGF positivity stain (%) within treatment groups. * P <0.05 vs control group, ** P <0.05 vs all groups. Abbreviations: ES, endostar; GEM, gemcitabine.

Article Snippet: The human recombinant endostatin, Endostar (rh-ES), was kindly provided by Shandong Simcere Medgenn Biopharmaceutical Co. (Yantai, Shandong, China) and stored at 4 °C.

Techniques: Expressing, Immunohistochemical staining, Staining, Control

Journal: Cancer Management and Research

Article Title: Antitumor effects of Endostar(rh-endostatin) combined with gemcitabine in different administration sequences to treat Lewis lung carcinoma

doi: 10.2147/CMAR.S192868

Figure Lengend Snippet: Expression of α-SMA in Lewis tumor tissue. ( A ) Immunohistochemical staining against α-SMA in xenografted Lewis treated with various treatment regimens (×200 magnification). ( B ) Number of α-SMA positive vessels within treatment groups. * P <0.05 vs control group, ** P <0.05 vs all groups. Abbreviations: ES, endostar; GEM, gemcitabine.

Article Snippet: The human recombinant endostatin, Endostar (rh-ES), was kindly provided by Shandong Simcere Medgenn Biopharmaceutical Co. (Yantai, Shandong, China) and stored at 4 °C.

Techniques: Expressing, Immunohistochemical staining, Staining, Control

Journal: Cancer Management and Research

Article Title: Antitumor effects of Endostar(rh-endostatin) combined with gemcitabine in different administration sequences to treat Lewis lung carcinoma

doi: 10.2147/CMAR.S192868

Figure Lengend Snippet: Organs morphology of mice from different groups. Hematoxylin-eosin staining of the heart, liver, spleen, lung, kidney in different groups. ( A ) Control group, ( B ) ES alone group, ( C ) GEM alone group, ( D ) ES/GEM group, ( E ) GEM/ES group, and ( F ) ES + GEM group. Abbreviations: ES, endostar; GEM, gemcitabine.

Article Snippet: The human recombinant endostatin, Endostar (rh-ES), was kindly provided by Shandong Simcere Medgenn Biopharmaceutical Co. (Yantai, Shandong, China) and stored at 4 °C.

Techniques: Staining, Control