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rest  (Cusabio)


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    Structured Review

    Cusabio rest
    Serum levels and prognostic value of <t>REST</t> protein in ALS patients (A) <t>ELISA</t> assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.
    Rest, supplied by Cusabio, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rest/product/Cusabio
    Average 93 stars, based on 4 article reviews
    rest - by Bioz Stars, 2026-04
    93/100 stars

    Images

    1) Product Images from "siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients"

    Article Title: siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients

    Journal: Molecular Therapy

    doi: 10.1016/j.ymthe.2025.10.039

    Serum levels and prognostic value of REST protein in ALS patients (A) ELISA assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.
    Figure Legend Snippet: Serum levels and prognostic value of REST protein in ALS patients (A) ELISA assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.

    Techniques Used: Enzyme-linked Immunosorbent Assay, Control, Sampling



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    Serum levels and prognostic value of <t>REST</t> protein in ALS patients (A) <t>ELISA</t> assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.
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    Image Search Results


    Serum levels and prognostic value of REST protein in ALS patients (A) ELISA assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.

    Journal: Molecular Therapy

    Article Title: siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients

    doi: 10.1016/j.ymthe.2025.10.039

    Figure Lengend Snippet: Serum levels and prognostic value of REST protein in ALS patients (A) ELISA assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.

    Article Snippet: Serum REST level was quantified by a human-specific ELISA kit specific for REST (Cusabio, American Research Products, Waltham, MA).

    Techniques: Enzyme-linked Immunosorbent Assay, Control, Sampling

    Serum levels and prognostic value of REST protein in ALS patients (A) ELISA assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.

    Journal: Molecular Therapy

    Article Title: siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients

    doi: 10.1016/j.ymthe.2025.10.039

    Figure Lengend Snippet: Serum levels and prognostic value of REST protein in ALS patients (A) ELISA assay results showing REST protein levels in the serum of ALS patients ( n = 56), compared with healthy controls (Ctrl) ( n = 23). ∗∗ p < 0.01 vs. control by Student’s t test. (B) Kaplan-Meier analysis of tracheostomy-free survival in ALS patients stratified according to the median serum REST protein levels. Patients with REST levels above the median, represented in red, exhibit a significantly worse prognosis than patients with levels below the median, shown in light green. (C and D) Univariate and multivariate Cox proportional hazard models assessing the prognostic value of increased serum REST levels, adjusted for bulbar onset type, sex, progression rate, and age at serum sampling. Whiskers represent the 95% confidence interval (CI). ∗ p < 0.05, ∗∗ p < 0.01.

    Article Snippet: Serum REST level was quantified by a human-specific ELISA kit specific for REST (Cusabio, American Research Products, Waltham, MA).

    Techniques: Enzyme-linked Immunosorbent Assay, Control, Sampling