Journal: PLOS One

Article Title: The novel mineralocorticoid receptor modulator balcinrenone protects against diet-induced cardiac microvascular dysfunction and plasma potassium elevation in mouse models

doi: 10.1371/journal.pone.0341078

Figure Lengend Snippet: (A) The amount of food consumed during the main study was monitored weekly and used to calculate the average doses of balcinrenone and eplerenone that each mouse received. (B) Myocardial perfusion before (rest) or after (stress) administration of 0.1 μg/g regadenoson. (C) MPR was calculated as: stress perfusion in mL/g/min divided by rest perfusion in mL/g/min, in mice after 20 weeks on the respective diets. Data are presented as means ± standard error. N = 14 or 15 for vehicle groups, N = 9 or 10 for treatment groups. bal, balcinrenone; eple, eplerenone; HFD, high-fat diet; MPR, myocardial perfusion reserve; RD, regular diet.

Article Snippet: An indwelling tail vein catheter was inserted to deliver 0.1 mmol/kg of gadolinium-diethylenetriamine pentaacetate acid (Magnevist ® ; Bayer, Berlin, Germany) and 0.1 μg/g of the pharmacological stress agent regadenoson (Lexiscan ® ; Astellas Pharma US Inc., Northbrook, IL, USA) during image acquisition.

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