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IC 50 values of the novel 2-fluoroethoxy derivative TA5 for the inhibition of human PDE2A and human PDE10A compared to our already published data for the lead compound TA1 and the PDE2A ligands TA2 – 4 [ <xref ref-type= 13 , 19 , 20 ]." width="100%" height="100%">

Journal: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Article Title: Investigation of an 18 F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

doi: 10.3390/molecules23030556

Figure Lengend Snippet: IC 50 values of the novel 2-fluoroethoxy derivative TA5 for the inhibition of human PDE2A and human PDE10A compared to our already published data for the lead compound TA1 and the PDE2A ligands TA2 – 4 [ 13 , 19 , 20 ].

Article Snippet: The inhibitory potencies of TA1 – 5 for human recombinant PDE2A and PDE10A proteins were determined by BioCrea GmbH (Radebeul, Germany) [ ].

Techniques: Inhibition