Journal: Pharmaceutics

Article Title: Extracellular Vesicles as New Players in Drug Delivery: A Focus on Red Blood Cells-Derived EVs

doi: 10.3390/pharmaceutics15020365

Figure Lengend Snippet: RBCEVs platform for clinical exploitation. The figure represents the road for the clinical exploitation of RBC-derived EVs, which could be achieved in the near future, and shows some of the advantages of this promising strategy. Created in Biorender.com , accessed on 14 December 2022.

Article Snippet: Finally, at the end of the year, Erytech Pharma also filed a patent application for the development of drug delivery RBCEVs from preloaded RBC (WO 2021/228832 A1, red blood cell extracellular vesicles (RCEVS) containing cargoes and methods of use and production thereof, 2021).

Techniques: Derivative Assay

Journal: Pharmaceutics

Article Title: Extracellular Vesicles as New Players in Drug Delivery: A Focus on Red Blood Cells-Derived EVs

doi: 10.3390/pharmaceutics15020365

Figure Lengend Snippet: Methods for cargo loading in RBCEVs. Loading methods have been divided into two main classes, namely pre-loading and post-loading methods. In the first, the cargo is loaded into the donor cell before the vesiculation process. While, in the second method, the cargo is loaded into the already produced vesicles. Created in Biorender.com , accessed on 9 January 2023.

Article Snippet: Recently, Erytech Pharma patented a novel vesiculation method to produce large-scale RBCEVs also based on “shear stress”.

Techniques: Produced