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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 <t>µg/mL</t> <t>R-848</t> or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).
R 848, supplied by InvivoGen, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/r-848/R848/pmc12985629-167-0-16
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resiquimod r 848  (Tocris)
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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 <t>µg/mL</t> <t>R-848</t> or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).
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resiquimod r 848 - by Bioz Stars, 2026-09
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tlr7 ligand r 848  (InvivoGen)
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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 <t>µg/mL</t> <t>R-848</t> or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).
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r 848  (Cambridge Bioscience)
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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 <t>µg/mL</t> <t>R-848</t> or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).
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nbp2 26231 5mg  (Novus Biologicals)
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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 <t>µg/mL</t> <t>R-848</t> or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).
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resiquimod r 848  (Novus Biologicals)
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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 <t>µg/mL</t> <t>R-848</t> or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).
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resiquimod r 848 - by Bioz Stars, 2026-09
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receptor 7 agonist r 848  (Mabtech Inc)
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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 <t>µg/mL</t> <t>R-848</t> or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).
Receptor 7 Agonist R 848, supplied by Mabtech Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 µg/mL R-848 or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).

Journal: International Journal of Molecular Sciences

Article Title: Bovine Lactoferrin Modulates Mononuclear Cell Activity in Human Palatine Tonsils

doi: 10.3390/ijms27052442

Figure Lengend Snippet: Inflammatory cytokine concentration in the culture supernatants of tonsillar mononuclear cells (TMCs). ( a ) Interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations under no TLR stimulation. ( b ) IL-6 and TNF-α concentrations under TLR7 stimulation. ( c ) IL-6 and TNF-α concentrations under TLR9 stimulation. After overnight incubation of TMCs from recurrent tonsillitis (RT) and immunoglobulin A nephropathy (IgAN) patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 µg/mL R-848 or 1 µM deoxycytidyl-deoxyguanosine oligonucleotides (CpG-ODN), IL-6, and TNF-α concentration in culture supernatants were measured using enzyme-linked immunosorbent assays (ELISAs). White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test).

Article Snippet: R-848, a TLR7/8 agonist, and class A CpG-ODN (ODN 2216), a TLR9 agonist, were purchased from InvivoGen (San Diego, CA, USA).

Techniques: Concentration Assay, Incubation, Control

Expression levels of activation markers in the immune cells under TLR7 stimulation. ( a ) Cell-surface HLA-DR, CD86, intracellular IFN-α, BAFF, and APRIL in pDCs. ( b ) Cell-surface HLA-DR and CD86 in mDCs. ( c ) Cell-surface CD69 in T-helper cells. ( d ) Cell-surface CD69 in T-killer cells. ( e ) Cell-surface CD69, CD86 and intracellular IgA in B cells. ( f ) Cell-surface CD69 and intracellular IFN-γ in NK cells. After overnight incubation of TMCs from RT and IgAN patients with 100 µg/mL LF and 10 µg/mL R-848, the expression levels of immune-cell activity markers were measured using flow cytometry. White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 3–7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test). IgAN, immunoglobulin A nephropathy; mDC, myeloid dendritic cell; LF, lactoferrin; MFI, geometric mean fluorescence intensity; NK, natural killer; pDC, plasmacytoid dendritic cell; RT, recurrent tonsillitis; TMCs, tonsillar mononuclear cells.

Journal: International Journal of Molecular Sciences

Article Title: Bovine Lactoferrin Modulates Mononuclear Cell Activity in Human Palatine Tonsils

doi: 10.3390/ijms27052442

Figure Lengend Snippet: Expression levels of activation markers in the immune cells under TLR7 stimulation. ( a ) Cell-surface HLA-DR, CD86, intracellular IFN-α, BAFF, and APRIL in pDCs. ( b ) Cell-surface HLA-DR and CD86 in mDCs. ( c ) Cell-surface CD69 in T-helper cells. ( d ) Cell-surface CD69 in T-killer cells. ( e ) Cell-surface CD69, CD86 and intracellular IgA in B cells. ( f ) Cell-surface CD69 and intracellular IFN-γ in NK cells. After overnight incubation of TMCs from RT and IgAN patients with 100 µg/mL LF and 10 µg/mL R-848, the expression levels of immune-cell activity markers were measured using flow cytometry. White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 3–7. * Significantly different from the control group ( p < 0.05, paired Student’s t -test). IgAN, immunoglobulin A nephropathy; mDC, myeloid dendritic cell; LF, lactoferrin; MFI, geometric mean fluorescence intensity; NK, natural killer; pDC, plasmacytoid dendritic cell; RT, recurrent tonsillitis; TMCs, tonsillar mononuclear cells.

Article Snippet: R-848, a TLR7/8 agonist, and class A CpG-ODN (ODN 2216), a TLR9 agonist, were purchased from InvivoGen (San Diego, CA, USA).

Techniques: Expressing, Activation Assay, Incubation, Activity Assay, Flow Cytometry, Control, Fluorescence

Galactose-deficient IgA1 (Gd-IgA1), BAFF, and APRIL concentrations in the culture supernatants of TMCs. ( a ) Gd-IgA1, BAFF, and APRIL concentrations under no TLR stimulation. ( b ) Gd-IgA1, BAFF, and APRIL concentrations under TLR7 stimulation. ( c ) Gd-IgA1, BAFF, and APRIL concentrations under TLR9 stimulation. After overnight incubation of TMCs from RT and IgAN patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 µg/mL R-848 or 1 µM CpG-ODN, the concentrations of Gd-IgA1, BAFF, and APRIL in culture supernatants were measured using ELISA. White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 3–8. * Significantly different from the control group ( p < 0.05, paired Student’s t -test). CpG-ODN, deoxycytidyl-deoxyguanosine oligodeoxynucleotide; IgAN, immunoglobulin A nephropathy; LF, lactoferrin; RT, recurrent tonsillitis; TMCs, tonsillar mononuclear cells.

Journal: International Journal of Molecular Sciences

Article Title: Bovine Lactoferrin Modulates Mononuclear Cell Activity in Human Palatine Tonsils

doi: 10.3390/ijms27052442

Figure Lengend Snippet: Galactose-deficient IgA1 (Gd-IgA1), BAFF, and APRIL concentrations in the culture supernatants of TMCs. ( a ) Gd-IgA1, BAFF, and APRIL concentrations under no TLR stimulation. ( b ) Gd-IgA1, BAFF, and APRIL concentrations under TLR7 stimulation. ( c ) Gd-IgA1, BAFF, and APRIL concentrations under TLR9 stimulation. After overnight incubation of TMCs from RT and IgAN patients with 100 µg/mL lactoferrin (LF) in the presence or absence of 10 µg/mL R-848 or 1 µM CpG-ODN, the concentrations of Gd-IgA1, BAFF, and APRIL in culture supernatants were measured using ELISA. White bars represent the control group, and gray bars represent the LF-treated group. Values are presented as the mean and SD. Black circles represent individual values. n = 3–8. * Significantly different from the control group ( p < 0.05, paired Student’s t -test). CpG-ODN, deoxycytidyl-deoxyguanosine oligodeoxynucleotide; IgAN, immunoglobulin A nephropathy; LF, lactoferrin; RT, recurrent tonsillitis; TMCs, tonsillar mononuclear cells.

Article Snippet: R-848, a TLR7/8 agonist, and class A CpG-ODN (ODN 2216), a TLR9 agonist, were purchased from InvivoGen (San Diego, CA, USA).

Techniques: Incubation, Enzyme-linked Immunosorbent Assay, Control