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Journal: Frontiers in Pharmacology
Article Title: Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager
doi: 10.3389/fphar.2023.1163432
Figure Lengend Snippet: QSP Model Diagram. The model is divided into of four compartments: central, peripheral, tumor, and tumor-draining lymph node, which describe cycles of immune activation in lymph nodes, T cell trafficking to the tumor, killing of cancer cells, immune evasion, and antigen release and lymphatic transport. nT, naïve T cell; aT, activated T cell; NO, nitric oxide; Arg-I, arginase I; Treg, regulatory T cell; Teff, effector T cell; Th, helper T cell; Texh, exhausted T cell; MDSC, myeloid derived suppresser cells; mAPC, mature antigen presenting cell. Cytokine degradation and cellular clearance were omitted in the diagram. Modified from ( ; ).
Article Snippet: The current QSP model is modified from our previously published
Techniques: Activation Assay, Derivative Assay, Modification