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Image Search Results
Journal: Neural Regeneration Research
Article Title: Biomaterial-based strategies: a new era in spinal cord injury treatment
doi: 10.4103/NRR.NRR-D-24-00844
Figure Lengend Snippet: Application of PCFS scaffolds loaded with CBD-NT-3 to boost functional neuronal growth and axonal regeneration for the treatment of SCI. (A) Schematic representation of SCI repair using PAO to create a biomimetic collagen scaffold with unique physical properties. (B, C) Immunofluorescence staining maps of Tuj-1 + and Map-2 + in the injured sites of the individual treatment groups. Scale bars: 1 mm (left) and 50 μm (right and below). (D) Quantitative analysis of the area of Tuj-1 + and Map-2 + cells at the injury site in the different treatment groups. * P < 0.05, ** P < 0.01, *** P < 0.001. Reprinted with permission from Zhao et al. (2024). Copyright 2024 Wiley‐VCH GmbH. CBD-NT-3: Collagen-binding domain-neurotrophin-3; DAPI: 4′,6-diamidino-2-phenylindole; EDC: N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide; LOCS: linear ordered collagen scaffolds; Map-2: microtubule-associated protein-2; NHS: N-hydroxysuccinimide; NSC: neural stem cell; PAO: plasma amine oxidase; PCFS: porous collagen fibers; SCI: spinal cord injury.
Article Snippet: Zhao et al. (2024) developed a
Techniques: Functional Assay, Immunofluorescence, Staining, Binding Assay, Clinical Proteomics