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Assigned DILI category (Chen et al. <xref ref-type= 2016 or literature alignment), plasma C max.tot values, f u values, MEC and AC 50 values for hLiMT’s and HepaRG spheroids in the high-content screening (HCS) and cellular ATP endpoints" width="100%" height="100%">

Journal: Archives of Toxicology

Article Title: The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development

doi: 10.1007/s00204-020-02763-w

Figure Lengend Snippet: Assigned DILI category (Chen et al. 2016 or literature alignment), plasma C max.tot values, f u values, MEC and AC 50 values for hLiMT’s and HepaRG spheroids in the high-content screening (HCS) and cellular ATP endpoints

Article Snippet: AstraZeneca evaluated the use of a human liver-chip model versus a PHH liver spheroid model for acetaminophen (APAP) and fialuridine (FIAU).

Techniques: Clinical Proteomics, High Content Screening, Tandem Mass Spectroscopy