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The chemical structure of [ 99m Tc]Tc-TECANT-1.

Journal: Pharmaceutics

Article Title: Development of the 99m Tc-Labelled SST 2 Antagonist TECANT-1 for a First-in-Man Multicentre Clinical Study

doi: 10.3390/pharmaceutics15030885

Figure Lengend Snippet: The chemical structure of [ 99m Tc]Tc-TECANT-1.

Article Snippet: TECANT-1 (N4-p-Cl-Phe-cyclo(D-Cys-Tyr-D-Aph(Cbm)-Lys-Thr-Cys)-D-Tyr-NH 2 , where D-Aph(Cbm): D-4-amino-carbamoyl-phenylalanine) and TECANT-2 (N4-p-Cl-Phe-cyclo(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH 2 ) were custom made by piChem (Raaba-Grambach, Austria).

Techniques:

Representative radio-(RP)HPLC chromatogram of [ 99m Tc]Tc-TECANT-1 and [ 99m Tc]TcO 4 − eluate.

Journal: Pharmaceutics

Article Title: Development of the 99m Tc-Labelled SST 2 Antagonist TECANT-1 for a First-in-Man Multicentre Clinical Study

doi: 10.3390/pharmaceutics15030885

Figure Lengend Snippet: Representative radio-(RP)HPLC chromatogram of [ 99m Tc]Tc-TECANT-1 and [ 99m Tc]TcO 4 − eluate.

Article Snippet: TECANT-1 (N4-p-Cl-Phe-cyclo(D-Cys-Tyr-D-Aph(Cbm)-Lys-Thr-Cys)-D-Tyr-NH 2 , where D-Aph(Cbm): D-4-amino-carbamoyl-phenylalanine) and TECANT-2 (N4-p-Cl-Phe-cyclo(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH 2 ) were custom made by piChem (Raaba-Grambach, Austria).

Techniques:

% of [ 99m Tc]Tc-TECANT-1 purity in dependence on the amount of the precursor, reaction time and the pH of the reaction solution, determined by HPLC.

Journal: Pharmaceutics

Article Title: Development of the 99m Tc-Labelled SST 2 Antagonist TECANT-1 for a First-in-Man Multicentre Clinical Study

doi: 10.3390/pharmaceutics15030885

Figure Lengend Snippet: % of [ 99m Tc]Tc-TECANT-1 purity in dependence on the amount of the precursor, reaction time and the pH of the reaction solution, determined by HPLC.

Article Snippet: TECANT-1 (N4-p-Cl-Phe-cyclo(D-Cys-Tyr-D-Aph(Cbm)-Lys-Thr-Cys)-D-Tyr-NH 2 , where D-Aph(Cbm): D-4-amino-carbamoyl-phenylalanine) and TECANT-2 (N4-p-Cl-Phe-cyclo(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH 2 ) were custom made by piChem (Raaba-Grambach, Austria).

Techniques: