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ph-reversible crosslinking  (Intezyne Inc)
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Intezyne Inc ph-reversible crosslinking
The IVECT polymer micelle. Drugs are loaded into the core hydrophobic block (yellow). The <t>crosslinking</t> block (green) provides stability to the micelle by forming pH-reversible metal-acetate bonds that allow for triggered drug release near the tumor. The PEG block (gray) gives the micelle aqueous solubility and stealth properties in vivo .
Ph Reversible Crosslinking, supplied by Intezyne Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ph-reversible+crosslinking/pmc03306987-113-16-12?v=Intezyne+Inc
Average 90 stars, based on 1 article reviews
ph-reversible crosslinking - by Bioz Stars, 2026-08
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The IVECT polymer micelle. Drugs are loaded into the core hydrophobic block (yellow). The crosslinking block (green) provides stability to the micelle by forming pH-reversible metal-acetate bonds that allow for triggered drug release near the tumor. The PEG block (gray) gives the micelle aqueous solubility and stealth properties in vivo .

Journal: Journal of Drug Delivery

Article Title: A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs

doi: 10.1155/2012/951741

Figure Lengend Snippet: The IVECT polymer micelle. Drugs are loaded into the core hydrophobic block (yellow). The crosslinking block (green) provides stability to the micelle by forming pH-reversible metal-acetate bonds that allow for triggered drug release near the tumor. The PEG block (gray) gives the micelle aqueous solubility and stealth properties in vivo .

Article Snippet: In contrast to crosslinking in the core or periphery of the micelle, Intezyne has developed pH-reversible crosslinking technology in the middle block of the triblock copolymer.

Techniques: Polymer, Blocking Assay, Solubility, In Vivo

Metal-acetate crosslinking chemistry for stabilization of polymer micelles. While the drug is localized in the core block, the poly(aspartic acid) block of the middle block reacts with metals to form metal acetate bonds. Bonds are formed at high pH and are dissociated at low pH. M represents metal, and X represents a halogen.

Journal: Journal of Drug Delivery

Article Title: A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs

doi: 10.1155/2012/951741

Figure Lengend Snippet: Metal-acetate crosslinking chemistry for stabilization of polymer micelles. While the drug is localized in the core block, the poly(aspartic acid) block of the middle block reacts with metals to form metal acetate bonds. Bonds are formed at high pH and are dissociated at low pH. M represents metal, and X represents a halogen.

Article Snippet: In contrast to crosslinking in the core or periphery of the micelle, Intezyne has developed pH-reversible crosslinking technology in the middle block of the triblock copolymer.

Techniques: Polymer, Blocking Assay

Drug formulation properties. The encapsulation retention percentage, crosslinking retention percentage, and particle sizes are shown for eleven compounds tested for loading within the polymer micelle.

Journal: Journal of Drug Delivery

Article Title: A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs

doi: 10.1155/2012/951741

Figure Lengend Snippet: Drug formulation properties. The encapsulation retention percentage, crosslinking retention percentage, and particle sizes are shown for eleven compounds tested for loading within the polymer micelle.

Article Snippet: In contrast to crosslinking in the core or periphery of the micelle, Intezyne has developed pH-reversible crosslinking technology in the middle block of the triblock copolymer.

Techniques: Drug Formulation, Encapsulation, Polymer