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Injectable nanovesicle formulation made from enzyme-based glucose-responsive nanovesicle-embedded thermo-responsive matrix ( A ) Schematic of enzyme-based glucose-responsive nanovesicle and chemical structure of pH-sensitive copolymer PEG-poly(Ser-Ketal) (inset); ( B ) Immediate formation of hydrogel from nanovesicle integrated with thermo-responsive <t>PF127</t> solution at 37 °C (left) in vitro and 3 min after subcutaneous injection (right). (Reprinted with permission from ).
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Injectable nanovesicle formulation made from enzyme-based glucose-responsive nanovesicle-embedded thermo-responsive matrix ( A ) Schematic of enzyme-based glucose-responsive nanovesicle and chemical structure of pH-sensitive copolymer PEG-poly(Ser-Ketal) (inset); ( B ) Immediate formation of hydrogel from nanovesicle integrated with thermo-responsive PF127 solution at 37 °C (left) in vitro and 3 min after subcutaneous injection (right). (Reprinted with permission from ).

Journal: Polymers

Article Title: Glucose Oxidase-Based Glucose-Sensitive Drug Delivery for Diabetes Treatment

doi: 10.3390/polym9070255

Figure Lengend Snippet: Injectable nanovesicle formulation made from enzyme-based glucose-responsive nanovesicle-embedded thermo-responsive matrix ( A ) Schematic of enzyme-based glucose-responsive nanovesicle and chemical structure of pH-sensitive copolymer PEG-poly(Ser-Ketal) (inset); ( B ) Immediate formation of hydrogel from nanovesicle integrated with thermo-responsive PF127 solution at 37 °C (left) in vitro and 3 min after subcutaneous injection (right). (Reprinted with permission from ).

Article Snippet: The vesicles were mixed with a thermo-responsive and biodegradable polymer Pluronic-127 (PF127) before subcutaneous injection to extend the long-term release intention.

Techniques: Formulation, In Vitro, Injection