Journal: American Journal of Nuclear Medicine and Molecular Imaging

Article Title: Multi-level otsu method to define metabolic tumor volume in positron emission tomography

doi:

Figure Lengend Snippet: Agreement between MTVs and actual volumes in NEMA IQ phantom

Article Snippet: The lesions in the phantom were segmented using 4 approaches: 1) MO-PET, 2) gradient-based method using PETedge tool in MIMvista software, 3) conventional threshold methods which are relative threshold methods (20%, 40%, 60%, or 80% of the maximum activity), and 4) four background threshold methods (mean background +1 or +2 standard deviations, and mean background × 2 or × 2.5).

Techniques:

Journal: American Journal of Nuclear Medicine and Molecular Imaging

Article Title: Multi-level otsu method to define metabolic tumor volume in positron emission tomography

doi:

Figure Lengend Snippet: Representative NEMA IQ phantom PET image to compare accuracy between segmentation methods. A. In LBR 1.5:1, MO-PET and PETedge showed relatively accurate segmentation in three largest lesions in the phantom (diameter = 3.7, 2.8 and 2.2 cm) but 60% relative threshold overestimated the volumes in two lesions with diameters of 2.8 and 2.2 cm. B. In LBR 4:1 phantom, MO-PET (light blue colored ROI), and 60% relative threshold (green colored ROI) showed relatively accurate segmentation in two smallest lesions (diameter = 1.3, and 1 cm). However, PETedge (pink colored ROI) underestimated the actual volume of the two lesions. Upper row: CT, middle row: PET, lower row: PET/CT.

Article Snippet: The lesions in the phantom were segmented using 4 approaches: 1) MO-PET, 2) gradient-based method using PETedge tool in MIMvista software, 3) conventional threshold methods which are relative threshold methods (20%, 40%, 60%, or 80% of the maximum activity), and 4) four background threshold methods (mean background +1 or +2 standard deviations, and mean background × 2 or × 2.5).

Techniques: Positron Emission Tomography-Computed Tomography

Journal: American Journal of Nuclear Medicine and Molecular Imaging

Article Title: Multi-level otsu method to define metabolic tumor volume in positron emission tomography

doi:

Figure Lengend Snippet: MO-PET and PETedge segmentation in a patient with osteosarcoma. Repeated independent measurements using MO-PET (blue and light blue colored ROIs) and PETedge (red and pink colored ROIs) showed excellent intra-method agreements with the minor discrepancy. Note that the tumor portion with a low FDG uptake was included in PETedge segmentation but excluded in MO-PET segmentation.

Article Snippet: The lesions in the phantom were segmented using 4 approaches: 1) MO-PET, 2) gradient-based method using PETedge tool in MIMvista software, 3) conventional threshold methods which are relative threshold methods (20%, 40%, 60%, or 80% of the maximum activity), and 4) four background threshold methods (mean background +1 or +2 standard deviations, and mean background × 2 or × 2.5).

Techniques:

Journal: American Journal of Nuclear Medicine and Molecular Imaging

Article Title: Multi-level otsu method to define metabolic tumor volume in positron emission tomography

doi:

Figure Lengend Snippet: Intra-class correlation and Bland-Altman analysis of measurements using MO-PET and PETedge segmentation

Article Snippet: The lesions in the phantom were segmented using 4 approaches: 1) MO-PET, 2) gradient-based method using PETedge tool in MIMvista software, 3) conventional threshold methods which are relative threshold methods (20%, 40%, 60%, or 80% of the maximum activity), and 4) four background threshold methods (mean background +1 or +2 standard deviations, and mean background × 2 or × 2.5).

Techniques:

Journal: American Journal of Nuclear Medicine and Molecular Imaging

Article Title: Multi-level otsu method to define metabolic tumor volume in positron emission tomography

doi:

Figure Lengend Snippet: Bland-Altman plot for repeated measurement using MO-PET and PETedge. Repeated measurements of MTV, SUVmean, and TLG using (A) MO-PET and (B) PETedge showed excellent agreements. (C) However, measurements of MTV, SUVmean, and TLG between MO-PET and PETedge showed substantial variation.

Article Snippet: The lesions in the phantom were segmented using 4 approaches: 1) MO-PET, 2) gradient-based method using PETedge tool in MIMvista software, 3) conventional threshold methods which are relative threshold methods (20%, 40%, 60%, or 80% of the maximum activity), and 4) four background threshold methods (mean background +1 or +2 standard deviations, and mean background × 2 or × 2.5).

Techniques:

Journal: American Journal of Nuclear Medicine and Molecular Imaging

Article Title: Multi-level otsu method to define metabolic tumor volume in positron emission tomography

doi:

Figure Lengend Snippet: Event free survival time and hazard ratio

Article Snippet: The lesions in the phantom were segmented using 4 approaches: 1) MO-PET, 2) gradient-based method using PETedge tool in MIMvista software, 3) conventional threshold methods which are relative threshold methods (20%, 40%, 60%, or 80% of the maximum activity), and 4) four background threshold methods (mean background +1 or +2 standard deviations, and mean background × 2 or × 2.5).

Techniques:

Journal: American Journal of Nuclear Medicine and Molecular Imaging

Article Title: Multi-level otsu method to define metabolic tumor volume in positron emission tomography

doi:

Figure Lengend Snippet: Prediction of event free survival (EFS) using MTV (MO-PET) and MTV (PETedge). (A) ROC curves of MTV (MO-PET) and MTV (PETedge) for prediction of the event at two years. MTV (MO-PET) and MTV (PETedge) showed the similar area under curve (AUC) of 0.771, 0.781 respectively for prediction of the event at two years. Kaplan-Meyer curves between low and high MTV groups classified by (B) MTV (MO-PET) and (C) MTV (PETedge). (D) EFS was longest in low MTV group followed by high MTV (MO-PET or PETedge) group and high MTV (MO-PET and PETedge) group (P for trend = 0.0002). Low MTV (MO PET and PETedge) = patient group with low MTV by MTV (MO-PET) and MTV (PETedge), high MTV (MO-PET or PETedge) = patient group with high MTV by either MTV (MO-PET) or MTV (PETedge), high MTV (MO-PET and PETedge) = patient group with high MTV by both MTV (MO-PET) and MTV (PETedge).

Article Snippet: The lesions in the phantom were segmented using 4 approaches: 1) MO-PET, 2) gradient-based method using PETedge tool in MIMvista software, 3) conventional threshold methods which are relative threshold methods (20%, 40%, 60%, or 80% of the maximum activity), and 4) four background threshold methods (mean background +1 or +2 standard deviations, and mean background × 2 or × 2.5).

Techniques: