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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
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pcat  (Medis)
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
Pcat, supplied by Medis, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ampr  (Addgene inc)
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
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pcat 000 based backbone  (Addgene inc)
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
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basic pcat vector  (Promega)
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
Basic Pcat Vector, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recording plasmid pfs 0453  (Addgene inc)
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
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plasmid pfs 0453  (Addgene inc)
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Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
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f42211b6 1d68 450d a6ae 1e0b80b67992 data availability statement plasmid pfs 0453  (Addgene inc)
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Addgene inc f42211b6 1d68 450d a6ae 1e0b80b67992 data availability statement plasmid pfs 0453
Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic <t>strategies:</t> <t>CTCA</t> (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and <t>PCAT</t> metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.
F42211b6 1d68 450d A6ae 1e0b80b67992 Data Availability Statement Plasmid Pfs 0453, supplied by Addgene inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pcat/pmc11163514-48-3-31?v=Addgene+inc
Average 91 stars, based on 1 article reviews
f42211b6 1d68 450d a6ae 1e0b80b67992 data availability statement plasmid pfs 0453 - by Bioz Stars, 2026-07
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Image Search Results


Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic strategies: CTCA (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and PCAT metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.

Journal: medRxiv

Article Title: CTCA-Based Pericoronary Fat and Anatomy–Flow Signatures Identify Future Culprit Lesions in Moderate Stenoses

doi: 10.64898/2026.05.12.26352858

Figure Lengend Snippet: Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic strategies: CTCA (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and PCAT metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.

Article Snippet: To reflect a clinically realistic CT diagnostic pathway, three nested models were constructed comprising: (1) lesion severity parameters obtainable directly from standard CTCA interpretation, (2) additional plaque composition and PCAT features requiring semi-automated post-processing (e.g., using MEDIS), and (3) lesion assessment incorporating centreline-based geometric descriptors and CFD-derived haemodynamic metrics.

Techniques: Derivative Assay, Diagnostic Assay

Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic strategies: CTCA (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and PCAT metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.

Journal: medRxiv

Article Title: CTCA-Based Pericoronary Fat and Anatomy–Flow Signatures Identify Future Culprit Lesions in Moderate Stenoses

doi: 10.64898/2026.05.12.26352858

Figure Lengend Snippet: Predicted cumulative risk across nested CT-based models in the overall cohort and the moderate-stenosis subset. Cox model–derived predicted cumulative risk curves are shown for three nested diagnostic strategies: CTCA (anatomical assessment alone), CTCA+MEDIS (addition of quantitative plaque and PCAT metrics), and CTCA+MEDIS+CFD (further incorporation of haemodynamic and geometric features). Left panel depicts all lesions; right panel shows lesions with moderate stenosis. Curves illustrate the stepwise separation of predicted risk with sequential model enrichment. P values annotate pairwise comparisons between nested models (likelihood ratio tests); * denotes statistical significance.

Article Snippet: In contrast, among moderate-stenosis lesions, inclusion of CFD-derived features was associated with an improvement beyond using basic CTCA features alone, with earlier divergence of risk curves in model fit compared with basic CTCA features and plaque components and PCAT volumes derived from MEDIS (p=0.007).

Techniques: Derivative Assay, Diagnostic Assay