Journal: ACS Omega

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions

doi: 10.1021/acsomega.4c10142

Figure Lengend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P17

Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Techniques:

Journal: ACS Omega

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions

doi: 10.1021/acsomega.4c10142

Figure Lengend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-P18

Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Techniques:

Journal: ACS Omega

Article Title: Structure–Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions

doi: 10.1021/acsomega.4c10142

Figure Lengend Snippet: Biodistribution a in PC3-PIP and PC3-flu Tumor-Bearing Balb/c Nude Mice at 1, 2, and 24 h p.i. of [ 177 Lu]Lu-PSMA-617

Article Snippet: In vitro assays were performed using the sublines of the androgen-independent PC3 human PCa cell line, PSMA-positive (PSMA+) PC3-PIP and PSMA-negative (PSMA−) PC3-flu cells, purchased from Johns Hopkins University (Baltimore, MA, USA).

Techniques:

Journal: Theranostics

Article Title: Auger radiopharmaceutical therapy targeting prostate-specific membrane antigen in a micrometastatic model of prostate cancer

doi: 10.7150/thno.38882

Figure Lengend Snippet: Biodistribution studies of 125 I-DCIBzL (18.5 MBq) in mice bearing PSMA+ PC3 PIP and PSMA- PC3 flu tumors show increased uptake in PSMA+ PIP tumors compared to kidneys and PSMA- flu tumors over 3 weeks. The PIP tumor:kidney ratio remained at 2-3:1 during this period. Note that kidney uptake at 1 hr and 24 hrs was too high to be evaluated by γ-counter. Values represent mean ± standard deviation. P <0.05 between PIP tumor and kidney at 2 weeks via t-test, non-significant at other time points.

Article Snippet: For studies evaluating biodistribution in tumor-bearing mice, NSG mice (Animal Resources core, Johns Hopkins, n=5/group) weighing 20-25 g were injected subcutaneously in the right and left flank areas with 1x10 6 PSMA+ PC3 PIP and 1x10 6 PSMA- PC3 flu cells, respectively.

Techniques: Standard Deviation