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pbpk model toolkit  (Disease Registry)
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Schematic overview of the <t>physiologically</t> <t>based</t> <t>pharmacokinetic</t> <t>(PBPK)</t> and signaling pathways for potential use in chemical mixtures assessment. A, Representation of the PBPK steps used. Recoding, evaluation, and application of the published (B) toluene, ethylbenzene, and xylene (TEX) PBPK model. B, Toluene, ethylbenzene, and xylene pathways analysis. Representation of the chemical/gene/disease’s interactions component. Use of published high-throughput analysis, toxicogenomic databases, and systems biology platforms to understand pathways impacted by chemical mixtures. C, PBPK/PD and signaling pathways. Representation of exploring the A and B components and future connecting directions.
Pbpk Model Toolkit, supplied by Disease Registry, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pbpk+model+toolkit/pmc08215597-104-12-6?v=Disease+Registry
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pbpk model toolkit - by Bioz Stars, 2026-07
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human pbpk model toolkit  (Disease Registry)
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Disease Registry human pbpk model toolkit
<t> Physiologically Based Pharmacokinetic </t> <t> (PBPK) </t> volatile organic compounds (VOCs) Model Comparison.
Human Pbpk Model Toolkit, supplied by Disease Registry, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pbpk+model+toolkit/pmc03233417-20-16-6?v=Disease+Registry
Average 90 stars, based on 1 article reviews
human pbpk model toolkit - by Bioz Stars, 2026-07
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Schematic overview of the physiologically based pharmacokinetic (PBPK) and signaling pathways for potential use in chemical mixtures assessment. A, Representation of the PBPK steps used. Recoding, evaluation, and application of the published (B) toluene, ethylbenzene, and xylene (TEX) PBPK model. B, Toluene, ethylbenzene, and xylene pathways analysis. Representation of the chemical/gene/disease’s interactions component. Use of published high-throughput analysis, toxicogenomic databases, and systems biology platforms to understand pathways impacted by chemical mixtures. C, PBPK/PD and signaling pathways. Representation of exploring the A and B components and future connecting directions.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Article Title: Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology

doi: 10.1093/toxsci/kfz243

Figure Lengend Snippet: Schematic overview of the physiologically based pharmacokinetic (PBPK) and signaling pathways for potential use in chemical mixtures assessment. A, Representation of the PBPK steps used. Recoding, evaluation, and application of the published (B) toluene, ethylbenzene, and xylene (TEX) PBPK model. B, Toluene, ethylbenzene, and xylene pathways analysis. Representation of the chemical/gene/disease’s interactions component. Use of published high-throughput analysis, toxicogenomic databases, and systems biology platforms to understand pathways impacted by chemical mixtures. C, PBPK/PD and signaling pathways. Representation of exploring the A and B components and future connecting directions.

Article Snippet: The Agency for Toxic Substances and Disease Registry (ATSDR) has developed a PBPK model toolkit, these are being recoded into a single language, Berkeley Madonna ( Emond et al., 2017 ; Mumtaz et al., 2012 ; Ruiz et al., 2010 ) and are validated and evaluated as part of the methods development.

Techniques: Protein-Protein interactions, High Throughput Screening Assay

Physiologically Based Pharmacokinetic (PBPK) volatile organic compounds (VOCs) Model Comparison.

Journal: International Journal of Molecular Sciences

Article Title: Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants

doi: 10.3390/ijms12117469

Figure Lengend Snippet: Physiologically Based Pharmacokinetic (PBPK) volatile organic compounds (VOCs) Model Comparison.

Article Snippet: The Agency for Toxic Substances and Disease Registry (ATSDR) has conducted translational research to develop a human PBPK model toolkit by recoding published PBPK models.

Techniques: Comparison

Comparison of Minimal Risk Level (MRL) simulated blood concentration of each solvent, assuming simultaneous inhalation (24 h/day) and oral ingestion (4 drinking bouts per day) to the measured blood concentration of solvent reported by National Health and Nutrition Examination Survey (NHANES) 2003–2004. The simulated solvent exposure is set to the MRL for inhalation of the solvent in air and ingestion of the solvent in water.

Journal: International Journal of Molecular Sciences

Article Title: Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants

doi: 10.3390/ijms12117469

Figure Lengend Snippet: Comparison of Minimal Risk Level (MRL) simulated blood concentration of each solvent, assuming simultaneous inhalation (24 h/day) and oral ingestion (4 drinking bouts per day) to the measured blood concentration of solvent reported by National Health and Nutrition Examination Survey (NHANES) 2003–2004. The simulated solvent exposure is set to the MRL for inhalation of the solvent in air and ingestion of the solvent in water.

Article Snippet: The Agency for Toxic Substances and Disease Registry (ATSDR) has conducted translational research to develop a human PBPK model toolkit by recoding published PBPK models.

Techniques: Comparison, Concentration Assay, Solvent