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Wogonin inhibited TLR4 to ameliorate renal injury via upregulation of SOCS3 in db/db mice. db/db mice were injected with adenovirus sh-SOCS3 or sh-SOCS3 + sh-TLR4, followed by treatment by vehicle or wogonin. ( A ) Blood glucose levels were measured using an automated chemistry analyzer. ( B ) The <t>pathological</t> features and glucose in the renal tissues were evaluated by hematoxylin, eosin (HE), and periodic acid-Schiff base (PAS). Scale bar = 50 μm. ( C - D ) The urinary protein, serum creatinine values (Scr), and blood urea nitrogen (BUN) were evaluated by an automated chemistry analyzer. ( E - F ) 24-hour albumin and urinary albumin-to-creatinine ratio (ACR) were detected by ELISA assay in HG mice without or with wogonin, wogonin + sh-SOCS3, wogonin + sh-SOCS3 + sh-TLR4 ( E ) ELISA evaluated the levels of cytokines. ( F - G ) The mRNA and protein levels of SOCS3 and TLR4 were detected by RT-qPCR and western blot, respectively. ( H ) The protein levels of collagen I, CTGF, FN, and TGF-β1 were detected by western blot assay. ( I ) The protein levels of ACE, Ang II, and AT1R were detected by western blot assay. ( J ) The protein levels of p-JAK2, JAK2, p-STAT1, STAT1, p-STAT3, STAT3, AIM2, ASC, caspase-1, IL-18 and IL-1β were detected by western blot assay. * P < 0.05, ** P < 0.01, *** P < 0.001 versus the corresponding control. Data are representative of three independent experiments
Pathological Structure Changes, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Wogonin inhibited TLR4 to ameliorate renal injury via upregulation of SOCS3 in db/db mice. db/db mice were injected with adenovirus sh-SOCS3 or sh-SOCS3 + sh-TLR4, followed by treatment by vehicle or wogonin. ( A ) Blood glucose levels were measured using an automated chemistry analyzer. ( B ) The <t>pathological</t> features and glucose in the renal tissues were evaluated by hematoxylin, eosin (HE), and periodic acid-Schiff base (PAS). Scale bar = 50 μm. ( C - D ) The urinary protein, serum creatinine values (Scr), and blood urea nitrogen (BUN) were evaluated by an automated chemistry analyzer. ( E - F ) 24-hour albumin and urinary albumin-to-creatinine ratio (ACR) were detected by ELISA assay in HG mice without or with wogonin, wogonin + sh-SOCS3, wogonin + sh-SOCS3 + sh-TLR4 ( E ) ELISA evaluated the levels of cytokines. ( F - G ) The mRNA and protein levels of SOCS3 and TLR4 were detected by RT-qPCR and western blot, respectively. ( H ) The protein levels of collagen I, CTGF, FN, and TGF-β1 were detected by western blot assay. ( I ) The protein levels of ACE, Ang II, and AT1R were detected by western blot assay. ( J ) The protein levels of p-JAK2, JAK2, p-STAT1, STAT1, p-STAT3, STAT3, AIM2, ASC, caspase-1, IL-18 and IL-1β were detected by western blot assay. * P < 0.05, ** P < 0.01, *** P < 0.001 versus the corresponding control. Data are representative of three independent experiments
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Wogonin inhibited TLR4 to ameliorate renal injury via upregulation of SOCS3 in db/db mice. db/db mice were injected with adenovirus sh-SOCS3 or sh-SOCS3 + sh-TLR4, followed by treatment by vehicle or wogonin. ( A ) Blood glucose levels were measured using an automated chemistry analyzer. ( B ) The <t>pathological</t> features and glucose in the renal tissues were evaluated by hematoxylin, eosin (HE), and periodic acid-Schiff base (PAS). Scale bar = 50 μm. ( C - D ) The urinary protein, serum creatinine values (Scr), and blood urea nitrogen (BUN) were evaluated by an automated chemistry analyzer. ( E - F ) 24-hour albumin and urinary albumin-to-creatinine ratio (ACR) were detected by ELISA assay in HG mice without or with wogonin, wogonin + sh-SOCS3, wogonin + sh-SOCS3 + sh-TLR4 ( E ) ELISA evaluated the levels of cytokines. ( F - G ) The mRNA and protein levels of SOCS3 and TLR4 were detected by RT-qPCR and western blot, respectively. ( H ) The protein levels of collagen I, CTGF, FN, and TGF-β1 were detected by western blot assay. ( I ) The protein levels of ACE, Ang II, and AT1R were detected by western blot assay. ( J ) The protein levels of p-JAK2, JAK2, p-STAT1, STAT1, p-STAT3, STAT3, AIM2, ASC, caspase-1, IL-18 and IL-1β were detected by western blot assay. * P < 0.05, ** P < 0.01, *** P < 0.001 versus the corresponding control. Data are representative of three independent experiments
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Wogonin inhibited TLR4 to ameliorate renal injury via upregulation of SOCS3 in db/db mice. db/db mice were injected with adenovirus sh-SOCS3 or sh-SOCS3 + sh-TLR4, followed by treatment by vehicle or wogonin. ( A ) Blood glucose levels were measured using an automated chemistry analyzer. ( B ) The <t>pathological</t> features and glucose in the renal tissues were evaluated by hematoxylin, eosin (HE), and periodic acid-Schiff base (PAS). Scale bar = 50 μm. ( C - D ) The urinary protein, serum creatinine values (Scr), and blood urea nitrogen (BUN) were evaluated by an automated chemistry analyzer. ( E - F ) 24-hour albumin and urinary albumin-to-creatinine ratio (ACR) were detected by ELISA assay in HG mice without or with wogonin, wogonin + sh-SOCS3, wogonin + sh-SOCS3 + sh-TLR4 ( E ) ELISA evaluated the levels of cytokines. ( F - G ) The mRNA and protein levels of SOCS3 and TLR4 were detected by RT-qPCR and western blot, respectively. ( H ) The protein levels of collagen I, CTGF, FN, and TGF-β1 were detected by western blot assay. ( I ) The protein levels of ACE, Ang II, and AT1R were detected by western blot assay. ( J ) The protein levels of p-JAK2, JAK2, p-STAT1, STAT1, p-STAT3, STAT3, AIM2, ASC, caspase-1, IL-18 and IL-1β were detected by western blot assay. * P < 0.05, ** P < 0.01, *** P < 0.001 versus the corresponding control. Data are representative of three independent experiments
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Wogonin inhibited TLR4 to ameliorate renal injury via upregulation of SOCS3 in db/db mice. db/db mice were injected with adenovirus sh-SOCS3 or sh-SOCS3 + sh-TLR4, followed by treatment by vehicle or wogonin. ( A ) Blood glucose levels were measured using an automated chemistry analyzer. ( B ) The pathological features and glucose in the renal tissues were evaluated by hematoxylin, eosin (HE), and periodic acid-Schiff base (PAS). Scale bar = 50 μm. ( C - D ) The urinary protein, serum creatinine values (Scr), and blood urea nitrogen (BUN) were evaluated by an automated chemistry analyzer. ( E - F ) 24-hour albumin and urinary albumin-to-creatinine ratio (ACR) were detected by ELISA assay in HG mice without or with wogonin, wogonin + sh-SOCS3, wogonin + sh-SOCS3 + sh-TLR4 ( E ) ELISA evaluated the levels of cytokines. ( F - G ) The mRNA and protein levels of SOCS3 and TLR4 were detected by RT-qPCR and western blot, respectively. ( H ) The protein levels of collagen I, CTGF, FN, and TGF-β1 were detected by western blot assay. ( I ) The protein levels of ACE, Ang II, and AT1R were detected by western blot assay. ( J ) The protein levels of p-JAK2, JAK2, p-STAT1, STAT1, p-STAT3, STAT3, AIM2, ASC, caspase-1, IL-18 and IL-1β were detected by western blot assay. * P < 0.05, ** P < 0.01, *** P < 0.001 versus the corresponding control. Data are representative of three independent experiments

Journal: Molecular Medicine

Article Title: Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway

doi: 10.1186/s10020-024-00845-4

Figure Lengend Snippet: Wogonin inhibited TLR4 to ameliorate renal injury via upregulation of SOCS3 in db/db mice. db/db mice were injected with adenovirus sh-SOCS3 or sh-SOCS3 + sh-TLR4, followed by treatment by vehicle or wogonin. ( A ) Blood glucose levels were measured using an automated chemistry analyzer. ( B ) The pathological features and glucose in the renal tissues were evaluated by hematoxylin, eosin (HE), and periodic acid-Schiff base (PAS). Scale bar = 50 μm. ( C - D ) The urinary protein, serum creatinine values (Scr), and blood urea nitrogen (BUN) were evaluated by an automated chemistry analyzer. ( E - F ) 24-hour albumin and urinary albumin-to-creatinine ratio (ACR) were detected by ELISA assay in HG mice without or with wogonin, wogonin + sh-SOCS3, wogonin + sh-SOCS3 + sh-TLR4 ( E ) ELISA evaluated the levels of cytokines. ( F - G ) The mRNA and protein levels of SOCS3 and TLR4 were detected by RT-qPCR and western blot, respectively. ( H ) The protein levels of collagen I, CTGF, FN, and TGF-β1 were detected by western blot assay. ( I ) The protein levels of ACE, Ang II, and AT1R were detected by western blot assay. ( J ) The protein levels of p-JAK2, JAK2, p-STAT1, STAT1, p-STAT3, STAT3, AIM2, ASC, caspase-1, IL-18 and IL-1β were detected by western blot assay. * P < 0.05, ** P < 0.01, *** P < 0.001 versus the corresponding control. Data are representative of three independent experiments

Article Snippet: Subsequently, hematoxylin and eosin were used to analyze the pathological structure changes (H&E, H-3502-NB, Novus Biologicals, LLC, CO, USA).

Techniques: Injection, Enzyme-linked Immunosorbent Assay, Quantitative RT-PCR, Western Blot, Control