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Journal: bioRxiv
Article Title: Engineering nanocondensate formation through sequence composition and patterning
doi: 10.64898/2026.02.17.706365
Figure Lengend Snippet: Optimization results for designing peptides with high phase separation propensity ( c dense ) and low interfacial tension ( γ ). (A) For random peptides and phase separating homopolymers, γ and c dense are strongly correlated. (B) Optimization converges within 8 iterations, yielding arginine- and tryptophan-rich Pareto-optimal sequences containing polyR patches. (C) Sequence feature analysis shows that net charge can, but does not necessarily, disrupt the γ – c dense correlation. (D) Constrained optimization limiting the number of aromatic amino acids and incorporating prior data converges rapidly to similar arginine-rich, positively charged sequences.
Article Snippet: For the exploitation component of the optimization, the
Techniques: Sequencing