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P‐PBPK modeling software (application areas, drugs, and major funding)

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: Predicting the correct dose in children: Role of computational Pediatric Physiological‐based pharmacokinetics modeling tools

doi: 10.1002/psp4.12883

Figure Lengend Snippet: P‐PBPK modeling software (application areas, drugs, and major funding)

Article Snippet: Miao Zhang et al. developed a P‐PBPK model of HCQ using Simcyp (version 9.5) and integrated antiviral effects into vitro.

Techniques: Software, Selection

P‐PBPK modeling software (application areas, drugs, and major funding)

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: Predicting the correct dose in children: Role of computational Pediatric Physiological‐based pharmacokinetics modeling tools

doi: 10.1002/psp4.12883

Figure Lengend Snippet: P‐PBPK modeling software (application areas, drugs, and major funding)

Article Snippet: In addition, in 2021, in the Bonner et al. work, the hydrocortisone P‐PBPK model developed in Simcyp (version 16.1) investigated the clinical dosing regimens.

Techniques: Software, Selection

Basic structure of p-PBPK model in (A) Gatsroplus (B) SimCyp and (C) Open Systems Pharmacology .

Journal: Frontiers in Pediatrics

Article Title: Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models

doi: 10.3389/fped.2021.733823

Figure Lengend Snippet: Basic structure of p-PBPK model in (A) Gatsroplus (B) SimCyp and (C) Open Systems Pharmacology .

Article Snippet: However, in the Open Systems Pharmacology software package, each of these units are considered discrete and accounted for separately, along with the inclusion of myometrium and endometrium, as seen in . summarizes the physiological parameters that are considered in the Simcyp p-PBPK model.

Techniques:

Physiological parameters that are modified for pregnancy prediction in Simcyp p-PBPK model.

Journal: Frontiers in Pediatrics

Article Title: Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models

doi: 10.3389/fped.2021.733823

Figure Lengend Snippet: Physiological parameters that are modified for pregnancy prediction in Simcyp p-PBPK model.

Article Snippet: However, in the Open Systems Pharmacology software package, each of these units are considered discrete and accounted for separately, along with the inclusion of myometrium and endometrium, as seen in . summarizes the physiological parameters that are considered in the Simcyp p-PBPK model.

Techniques: Modification, Activity Assay

Review of published p-PBPK models.

Journal: Frontiers in Pediatrics

Article Title: Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models

doi: 10.3389/fped.2021.733823

Figure Lengend Snippet: Review of published p-PBPK models.

Article Snippet: However, in the Open Systems Pharmacology software package, each of these units are considered discrete and accounted for separately, along with the inclusion of myometrium and endometrium, as seen in . summarizes the physiological parameters that are considered in the Simcyp p-PBPK model.

Techniques: Software, Activity Assay, In Vivo, Inhibition, Concentration Assay