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u2os human osteosarcoma cell line  (ATCC)
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ATCC u2os human osteosarcoma cell line
U2os Human Osteosarcoma Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human os cell line mg  (ATCC)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
Human Os Cell Line Mg, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human os cell lines mg63  (ATCC)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
Human Os Cell Lines Mg63, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human os cell lines  (ATCC)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
Human Os Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cell lines u2os cells atcc htb  (ATCC)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
Cell Lines U2os Cells Atcc Htb, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cell culture human os cell lines 143b  (ATCC)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
Cell Culture Human Os Cell Lines 143b, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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os cell lines  (Shanghai Biotechnology Co Ltd)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
Os Cell Lines, supplied by Shanghai Biotechnology Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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u2os htb 96 cell lines  (ATCC)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
U2os Htb 96 Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human os cell line mg63  (ATCC)
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
Human Os Cell Line Mg63, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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u2os human bone sarcoma cell line  (ATCC)
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ATCC u2os human bone sarcoma cell line
URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or <t>sh-URGCP</t> <t>MG-63</t> cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.
U2os Human Bone Sarcoma Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or sh-URGCP MG-63 cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.

Journal: Translational Cancer Research

Article Title: URGCP promotes osteosarcoma progression by regulating the ESCRT-III subunit CHMP4B

doi: 10.21037/tcr-2026-1420

Figure Lengend Snippet: URGCP silencing suppresses tumor growth and downregulates CHMP4B expression in vivo. (A) Images of excised tumors from mice injected with sh-NC or sh-URGCP MG-63 cells. n=6. (B) Tumor growth curves. (C) Final tumor volumes. (D) Tumor weights. (E,F) RT-qPCR analysis of URGCP (E) and CHMP4B (F) mRNA in tumor tissues. (G) Western blots of URGCP and CHMP4B. (H,I) Quantification of URGCP (H) and CHMP4B (I) protein expression. (J) H&E staining of tumor sections (scale: 100 μm). (K,L) IHC staining of URGCP (K) and CHMP4B (L) in tumors (scale: 100 μm). (M,N) Quantification of immunostains for URGCP (M) and CHMP4B (N) by IOD analysis. Data represent mean ± SD of at least three independent experiments. *, P<0.05; **, P<0.01; ***, P<0.001. H&E, hematoxylin and eosin; IHC, immunohistochemical; IOD, integrated optical density; OS, osteosarcoma; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SD, standard deviation; sh-NC, short hairpin RNA negative control; sh-URGCP, short hairpin RNA targeting URGCP; URGCP, upregulator of cell proliferation.

Article Snippet: The human OS cell line MG-63 was obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA).

Techniques: Expressing, In Vivo, Injection, Quantitative RT-PCR, Analysis, Western Blot, Staining, Immunohistochemistry, Immunohistochemical staining, Reverse Transcription, Real-time Polymerase Chain Reaction, Standard Deviation, shRNA, Negative Control