Journal: Journal of Nanobiotechnology

Article Title: Plasmonic platinum-tipped gold nanorods for tumor-targeted multimodal imaging diagnosis and NIR-II photothermal-catalytic-immuno synergetic therapy

doi: 10.1186/s12951-026-04246-z

Figure Lengend Snippet: Therapeutic effects of APINs in vivo. a Schematic diagram of the synergistic treatment process for unilateral NPC-bearing mice; b , c Time-dependent tumor growth curves of NPC-bearing mice with different treatments; d Tumor volumes, e tumor weights and f body weights of mice 18 days after different treatments; g HE, Ki67 staining images, and TUNEL, CD31 immunofluorescence images of tumor tissues after different treatments (scale bar: 200 μm); h Immunofluorescence staining images of CRT, HSP70, and HMGB1 of tumor tissues after different treatments respectively (scale bar: 50 μm); i HE staining images of lung from sacrificed NPC-bearing mice following different treatments, scale bar: 200 μm;. Mean ± SD, n = 5, * p < 0.05, ** p < 0.01, *** p < 0.001

Article Snippet: For in vivo photoacoustic imaging, NPC-bearing BALB/c mice were treated with APIN solutions (100 μL, 20 mg/kg) through intravenous injection ( n = 3) and PA imaging is accomplished by using an animal in vivo photoacoustic imaging system (Vevo LAZR, FUJIFILM Visual Sonics).

Techniques: In Vivo, Staining, TUNEL Assay, Immunofluorescence