Journal: Journal of Orthopaedic Translation

Article Title: Biomaterial-based strategies targeting ferroptosis for alleviating intervertebral disc degeneration: Advances and perspectives

doi: 10.1016/j.jot.2026.101148

Figure Lengend Snippet: Strategies and characterisation of nanoparticle-mediated delivery for mitigating ferroptosis in IVDD. (A) Schematic illustration of the synthesis of mPEG-PSA NPs from SA and its mechanism for mitigating IVDD as a therapeutic agent and the characterisation of mPEG-PSA NPs . Copyright 2025 Elsevier; (B) Schematic illustration of the mechanism by which NCH acts inside NPCs and characterization and preparation of PGA-Cu@SS08 . Copyright 2025 Wiley; (C) Schematic illustration of fullerol suppressing ferroptosis of NPCs to delay the process of IVDD and characterization of fullerol . Copyright 2025 Elsevier.

Article Snippet: Dynamic hydrogel , NPCs Sprague–Dawley rats , Oridonin Differentiation factor 5 , Nrf2 pathway↑ BMP pathway↑ , Ferroptosis↓ Inflammation↓ ECM synthesis↑ , Needle-puncture-induced disc degeneration model Intradiscally injection , Wang et al., 2023 [ ] .

Techniques:

Journal: Journal of Nanobiotechnology

Article Title: Plasmonic platinum-tipped gold nanorods for tumor-targeted multimodal imaging diagnosis and NIR-II photothermal-catalytic-immuno synergetic therapy

doi: 10.1186/s12951-026-04246-z

Figure Lengend Snippet: Therapeutic effects of APINs in vivo. a Schematic diagram of the synergistic treatment process for unilateral NPC-bearing mice; b , c Time-dependent tumor growth curves of NPC-bearing mice with different treatments; d Tumor volumes, e tumor weights and f body weights of mice 18 days after different treatments; g HE, Ki67 staining images, and TUNEL, CD31 immunofluorescence images of tumor tissues after different treatments (scale bar: 200 μm); h Immunofluorescence staining images of CRT, HSP70, and HMGB1 of tumor tissues after different treatments respectively (scale bar: 50 μm); i HE staining images of lung from sacrificed NPC-bearing mice following different treatments, scale bar: 200 μm;. Mean ± SD, n = 5, * p < 0.05, ** p < 0.01, *** p < 0.001

Article Snippet: For in vivo photoacoustic imaging, NPC-bearing BALB/c mice were treated with APIN solutions (100 μL, 20 mg/kg) through intravenous injection ( n = 3) and PA imaging is accomplished by using an animal in vivo photoacoustic imaging system (Vevo LAZR, FUJIFILM Visual Sonics).

Techniques: In Vivo, Staining, TUNEL Assay, Immunofluorescence