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Summary of major MSC clinical trials for ALS.

Journal: Stem Cells Translational Medicine

Article Title: Optimal Therapeutic Strategy of Bone Marrow-Originated Autologous Mesenchymal Stromal/Stem Cells for ALS

doi: 10.1093/stcltm/szad095

Figure Lengend Snippet: Summary of major MSC clinical trials for ALS.

Article Snippet: NCT01363401 , Korea/Corestem , Phase I , Two injections with a 26-day interval ( n = 7) , Autologous BM-MSCs (Lenzumestrocel, Neuronata-R® Inj) , Intrathecal , Safe , Oh et al. .

Techniques: Clinical Proteomics, Injection, Control

Summary of major MSC clinical trials for ALS.

Journal: Stem Cells Translational Medicine

Article Title: Optimal Therapeutic Strategy of Bone Marrow-Originated Autologous Mesenchymal Stromal/Stem Cells for ALS

doi: 10.1093/stcltm/szad095

Figure Lengend Snippet: Summary of major MSC clinical trials for ALS.

Article Snippet: NCT01363401 , Korea/Corestem , Phase II, RCT without a sham procedure , Randomized (1:1) (i) Two injections with a 26-day interval ( n = 32) (ii) Control group ( n = 27) , Autologous BM-MSCs (Lenzumestrocel, Neuronata-R® Inj) , Intrathecal , Safe; positive clinical effect, reduced pro-inflammatory cytokines , Oh et al. .

Techniques: Clinical Proteomics, Injection, Control

Clinical trials listed on clinicaltrials.gov for amyotrophic lateral sclerosis

Journal: Stem Cells Translational Medicine

Article Title: Neural Cells for Neurodegenerative Diseases in Clinical Trials

doi: 10.1093/stcltm/szad041

Figure Lengend Snippet: Clinical trials listed on clinicaltrials.gov for amyotrophic lateral sclerosis

Article Snippet: 13 , ALS , Corestem , Autologous BM MSC [Lenzumestrocel (Neuronata-R Inj.)] , IT , 2 M/kg or 5 M/kg , 115 , 2021 , 3 , NCT04745299.

Techniques: Clinical Proteomics, Expressing, Transplantation Assay, Injection