Journal: medRxiv

Article Title: Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimer’s disease

doi: 10.64898/2026.01.25.26344738

Figure Lengend Snippet: (A) and CDR-SB (B) with 18F-Flortaucipir tau PET binding in the CenTauR mesial temporal and universal ROIs and in voxel-based analyses. The binding data are also presented in CenTauR (CTR) units, following the Joint Propagation Model approach by Leuzy et al. Patients missing baseline MMSE or CDR-SB scores were excluded from the respective analyses. The linear coefficients for EOAD and LOAD are shown in orange and blue, respectively, and for the interaction in black. The voxel-wise analyses were adjusted for baseline Centiloid, sex, and years of education, and corrected for multiple comparisons using the FWE rate approach, as implemented in SPM12 software.

Article Snippet: His institution has received in-kind contributions for radiotracer precursors for tau-PET neuroimaging in studies of memory and aging (via Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly).

Techniques: Binding Assay, Software

Journal: medRxiv

Article Title: Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimer’s disease

doi: 10.64898/2026.01.25.26344738

Figure Lengend Snippet: (A), scatterplots showing age at baseline relative to the estimated annual rate of change in tau PET binding from the linear mixed-effects models (B), modeled group trajectories as a function of tau duration from the CenTauR threshold of 2 Z-scores using the SILA pipeline in the Universal ROI (C), and average baseline F-Flortaucipir tau PET scans across tau duration groups (D). The binding data are also presented in CenTauR (CTR) units, following the Joint Propagation Model approach by Leuzy et al. The linear mixed-effects models (B) were adjusted for baseline MMSE score, Centiloid, sex, and years of education, with random intercepts and slopes at the individual patient level. Patients missing baseline MMSE scores were excluded from the statistical modeling. The estimated annual rates of change in F Flortaucipir tau PET binding were derived from the sum of the fixed and random coefficients for each individual. The Pearson correlation coefficients for EOAD and LOAD are shown in orange and blue, respectively. The SILA models were anchored to the exploratory 2 CenTauR Z-score threshold, which was used to define F-Flortaucipir tau PET binding positivity, and the trajectories are modeled relative to time in years from crossing the threshold.

Article Snippet: His institution has received in-kind contributions for radiotracer precursors for tau-PET neuroimaging in studies of memory and aging (via Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly).

Techniques: Binding Assay, Derivative Assay

Journal: medRxiv

Article Title: Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimer’s disease

doi: 10.64898/2026.01.25.26344738

Figure Lengend Snippet:

Article Snippet: His institution has received in-kind contributions for radiotracer precursors for tau-PET neuroimaging in studies of memory and aging (via Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly).

Techniques: Binding Assay