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Strategy for substrate probe design based on dipeptidyl peptidase-IV (DPP-IV) inhibitors. A new fluorescent probe was obtained by connecting fluorescent groups to two inhibitors, alogliptin and linagliptin, which tightly bind to DPP-IV.

Journal: Journal of Pharmaceutical Analysis

Article Title: Techniques for the determination of dipeptidyl peptidase IV and screening of its inhibitors

doi: 10.1016/j.jpha.2025.101499

Figure Lengend Snippet: Strategy for substrate probe design based on dipeptidyl peptidase-IV (DPP-IV) inhibitors. A new fluorescent probe was obtained by connecting fluorescent groups to two inhibitors, alogliptin and linagliptin, which tightly bind to DPP-IV.

Article Snippet: These include sitagliptin (Merck), vildagliptin (Novartis), saxagliptin (AstraZeneca), alogliptin (Takeda), linagliptin (Eli Lilly), trelagliptin (Takeda), tiagliptin (Daiichi Sankyo/Mitsubishi Tanabe Pharma), cofrogliptin (Hesco) [ ], retagliptin (Henri) [ ], fotagliptin (Salubris) [ ], prusogliptin (Stone Pharmaceutical Group) [ ] and shengagliptin (Shengshi Taike) [ ].

Techniques: