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Smith & Nephew
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Anest Iwata
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BioMimetic Therapeutics
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Zhonghe Headway
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Sunmax Biotechnology
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Kartell Inc
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Hayek Inc
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KCI USA
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Journal: Cureus
Article Title: Pharmacokinetics of Continuous Local Antibiotic Perfusion in Fresh-Frozen Cadaver Models of Hip and Knee Arthroplasties
doi: 10.7759/cureus.104181
Figure Lengend Snippet: Schematic diagrams illustrating the experimental setup for intramedullary antibiotic perfusion (iMAP) in the hip joint models. (a) In the total hip arthroplasty (THA) model, a single iMAP pin was inserted from the iliac crest toward the acetabular region to deliver gentamicin into the iliac bone marrow, from which antibiotics could enter the joint cavity through marrow-joint communication. Intra-articular drainage was achieved using a Salem Sump™ tube connected to negative-pressure wound therapy. (b) In the bipolar hemiarthroplasty (BHA) model, the same iMAP and drainage configuration was used, with additional trans-acetabular perforations created to facilitate antibiotic flow from the iliac bone marrow into the joint cavity, thereby enhancing intra-articular perfusion NPWT: negative-pressure wound therapy
Article Snippet: The intra-articular soft tissue access and drainage system comprised a 20-French Salem SumpTM double-lumen tube (Cardinal Health, Dublin, OH) inserted by entry into the joint; its wider lumen was connected to a
Techniques:
Journal: Cureus
Article Title: Pharmacokinetics of Continuous Local Antibiotic Perfusion in Fresh-Frozen Cadaver Models of Hip and Knee Arthroplasties
doi: 10.7759/cureus.104181
Figure Lengend Snippet: Schematic diagrams illustrating the experimental setup for intramedullary antibiotic perfusion (iMAP) and intra-soft tissue antibiotic perfusion (iSAP) in the knee joint models. (a) In the native knee model, iMAP pins were placed in the femur and tibia to deliver antibiotics into the bone marrow, while a Salem Sump™ double-lumen tube was inserted intra-articularly to enable direct intra-articular infusion and continuous negative-pressure drainage (iSAP). (b) In the cemented total knee arthroplasty (TKA) model, iMAP pins were positioned adjacent to the cement-bone interface of the femoral and tibial components. Because cement fixation prevents marrow-joint communication, intra-articular antibiotic delivery and drainage were primarily achieved via the Salem Sump™ tube, allowing differentiation between intramedullary and intra-articular perfusion pathways NPWT: negative-pressure wound therapy
Article Snippet: The intra-articular soft tissue access and drainage system comprised a 20-French Salem SumpTM double-lumen tube (Cardinal Health, Dublin, OH) inserted by entry into the joint; its wider lumen was connected to a
Techniques: