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The effects of targeted MALAT1 on proinflammatory cytokines, IA formation, VSMC transformation, and the Smad pathway in IA rats. Effects of coinjection of MALAT1-silenced and SEMA3C-overexpressing <t>lentiviruses</t> on relative MALAT1 expression in IA tissue (A) , serum TNF-α (B) , serum IL-1β (C) , and serum IL-6 levels (D) , histological changes (E) , SEMA3C IHC scores (F) , α-SMA IHC scores, OPN IHC scores, MMP2 IHC scores, MMP9 IHC scores (G) , p-smad2 IHC scores and p-smad3 IHC scores (H) . * P < 0.05, ** P < 0.01, *** P < 0.001.
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The effects of targeted MALAT1 on proinflammatory cytokines, IA formation, VSMC transformation, and the Smad pathway in IA rats. Effects of coinjection of MALAT1-silenced and SEMA3C-overexpressing <t>lentiviruses</t> on relative MALAT1 expression in IA tissue (A) , serum TNF-α (B) , serum IL-1β (C) , and serum IL-6 levels (D) , histological changes (E) , SEMA3C IHC scores (F) , α-SMA IHC scores, OPN IHC scores, MMP2 IHC scores, MMP9 IHC scores (G) , p-smad2 IHC scores and p-smad3 IHC scores (H) . * P < 0.05, ** P < 0.01, *** P < 0.001.
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The effects of targeted MALAT1 on proinflammatory cytokines, IA formation, VSMC transformation, and the Smad pathway in IA rats. Effects of coinjection of MALAT1-silenced and SEMA3C-overexpressing lentiviruses on relative MALAT1 expression in IA tissue (A) , serum TNF-α (B) , serum IL-1β (C) , and serum IL-6 levels (D) , histological changes (E) , SEMA3C IHC scores (F) , α-SMA IHC scores, OPN IHC scores, MMP2 IHC scores, MMP9 IHC scores (G) , p-smad2 IHC scores and p-smad3 IHC scores (H) . * P < 0.05, ** P < 0.01, *** P < 0.001.

Journal: Frontiers in Cellular Neuroscience

Article Title: Silencing MALAT1 represses pathological progression, inflammation, and vascular smooth muscle cell phenotype switching by regulating the SEMA3C-mediated Smad pathway in intracranial aneurysms

doi: 10.3389/fncel.2026.1706518

Figure Lengend Snippet: The effects of targeted MALAT1 on proinflammatory cytokines, IA formation, VSMC transformation, and the Smad pathway in IA rats. Effects of coinjection of MALAT1-silenced and SEMA3C-overexpressing lentiviruses on relative MALAT1 expression in IA tissue (A) , serum TNF-α (B) , serum IL-1β (C) , and serum IL-6 levels (D) , histological changes (E) , SEMA3C IHC scores (F) , α-SMA IHC scores, OPN IHC scores, MMP2 IHC scores, MMP9 IHC scores (G) , p-smad2 IHC scores and p-smad3 IHC scores (H) . * P < 0.05, ** P < 0.01, *** P < 0.001.

Article Snippet: MALAT1 overexpression (oeMALAT1) lentivirus (Genechem, China), negative control overexpression (oeNC) lentivirus (Genechem, China), MALAT1 short hairpin (shMALAT1) lentivirus (Genechem, China) and negative control short hairpin (shNC) lentivirus (Genechem, China) were used to infect the VSMCs at a multiplicity of infection (MOI) of 20:1.

Techniques: Transformation Assay, Expressing