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gene exp myl2 mm00440384 m1  (Thermo Fisher)
86
Thermo Fisher gene exp myl2 mm00440384 m1
PCA of the three cardiac stromal populations and HL-1 cardiomyocytes. ( A ) PCA of the four cell populations shown: CTs ( n = 55), CDCs ( n = 41), and CFs ( n = 29) at passage 3, as well as HL-1 cardiomyocytes ( n = 13). Both CTs and CDCs represent 3 biological replicates. Dim.1 separates the cardiac stromal populations, whereas Dim.2 shows a distinct separation between cardiac stromal and myocyte populations. Gene loadings contributing to each Dim suggest that a small subset of genes explains the cross-group variability captured by Dim.1 and Dim.2. Tcf21 is associated with CTs (emphasised by the blue circle), whereas Tbx5 is associated with CDCs and CFs (emphasised by the brown circle). The separation between cardiac stromal and myocyte populations is reflected by clustering of core cardiac and cardiomyocyte genes ( Nkx2-5 , Wif1 , Nppa , <t>Myl2</t> , and Myh6 ), which are emphasised by the pink circle. ( B ) PCA of the three cardiac stromal populations alone: CTs ( n = 28), CDCs ( n = 41), and CFs ( n = 27). Both CTs and CDCs represent 3 biological replicates. Gene loadings contributing to each Dim show that Tcf21 is associated with CTs, whereas Tbx5 is associated with CDCs and CFs.
Gene Exp Myl2 Mm00440384 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myl2/Gene+Exp%2E+Myl2%2C+Mm00440384_m1/pmc12939824-63-2--1
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hcm d166v myl2  (Mutant Mouse Resource & Research Center)
86
Mutant Mouse Resource & Research Center hcm d166v myl2
PCA of the three cardiac stromal populations and HL-1 cardiomyocytes. ( A ) PCA of the four cell populations shown: CTs ( n = 55), CDCs ( n = 41), and CFs ( n = 29) at passage 3, as well as HL-1 cardiomyocytes ( n = 13). Both CTs and CDCs represent 3 biological replicates. Dim.1 separates the cardiac stromal populations, whereas Dim.2 shows a distinct separation between cardiac stromal and myocyte populations. Gene loadings contributing to each Dim suggest that a small subset of genes explains the cross-group variability captured by Dim.1 and Dim.2. Tcf21 is associated with CTs (emphasised by the blue circle), whereas Tbx5 is associated with CDCs and CFs (emphasised by the brown circle). The separation between cardiac stromal and myocyte populations is reflected by clustering of core cardiac and cardiomyocyte genes ( Nkx2-5 , Wif1 , Nppa , <t>Myl2</t> , and Myh6 ), which are emphasised by the pink circle. ( B ) PCA of the three cardiac stromal populations alone: CTs ( n = 28), CDCs ( n = 41), and CFs ( n = 27). Both CTs and CDCs represent 3 biological replicates. Gene loadings contributing to each Dim show that Tcf21 is associated with CTs, whereas Tbx5 is associated with CDCs and CFs.
Hcm D166v Myl2, supplied by Mutant Mouse Resource & Research Center, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myl2/male+wildtype+wt/10__1007_slash_s12551___026___01420___3-87-47-49
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hcm d166v myl2 - by Bioz Stars, 2026-09
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wildtype wt rlc myl2  (Mutant Mouse Resource & Research Center)
86
Mutant Mouse Resource & Research Center wildtype wt rlc myl2
PCA of the three cardiac stromal populations and HL-1 cardiomyocytes. ( A ) PCA of the four cell populations shown: CTs ( n = 55), CDCs ( n = 41), and CFs ( n = 29) at passage 3, as well as HL-1 cardiomyocytes ( n = 13). Both CTs and CDCs represent 3 biological replicates. Dim.1 separates the cardiac stromal populations, whereas Dim.2 shows a distinct separation between cardiac stromal and myocyte populations. Gene loadings contributing to each Dim suggest that a small subset of genes explains the cross-group variability captured by Dim.1 and Dim.2. Tcf21 is associated with CTs (emphasised by the blue circle), whereas Tbx5 is associated with CDCs and CFs (emphasised by the brown circle). The separation between cardiac stromal and myocyte populations is reflected by clustering of core cardiac and cardiomyocyte genes ( Nkx2-5 , Wif1 , Nppa , <t>Myl2</t> , and Myh6 ), which are emphasised by the pink circle. ( B ) PCA of the three cardiac stromal populations alone: CTs ( n = 28), CDCs ( n = 41), and CFs ( n = 27). Both CTs and CDCs represent 3 biological replicates. Gene loadings contributing to each Dim show that Tcf21 is associated with CTs, whereas Tbx5 is associated with CDCs and CFs.
Wildtype Wt Rlc Myl2, supplied by Mutant Mouse Resource & Research Center, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myl2/male+wildtype+wt/10__1007_slash_s12551___026___01420___3-87-68-71
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myl2  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc myl2
( A ) Representative images of Lamin A/C staining examine nuclear morphology in the cultured SuSCs (left panels) and calvarial cells (2 right panels). Graphs show quantitation of the average percentage of calvarial cells containing abnormal nuclear shape in 3 independent experiments ( P < 0.001 or 0.0005, n = 3, mean ± SD, 2-tailed Student’s t test). ( B ) Representative images showing immunostaining of phosphorylated myosin light chain 2 <t>(MYL2),</t> fascin1 (FSCN1), SUN2, and GM130 in the indicated cells. DAPI counterstaining in all images. ( C ) Representative images of filamentous actin (F-actin) staining examine the cytoskeleton of calvarial cells isolated from Lmna +/+ (WT) and Lmna L648R/L648R ( Lmna L648R ) mice. Graphs indicate quantitation of the average intensity of F-actin in 5 independent experiments ( P < 0.003, n = 3, mean ± SEM, 2-tailed Student’s t test). Scale bars: 50 μm ( A and C ), 20 μm ( B ).
Myl2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myl2/Phospho-Myosin+Light+Chain+2+(Ser19)+Antibody/pmc13041684-162-38-41
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gene exp myl2 hs00166405 m1  (Thermo Fisher)
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Thermo Fisher gene exp myl2 hs00166405 m1
( A ) Representative images of Lamin A/C staining examine nuclear morphology in the cultured SuSCs (left panels) and calvarial cells (2 right panels). Graphs show quantitation of the average percentage of calvarial cells containing abnormal nuclear shape in 3 independent experiments ( P < 0.001 or 0.0005, n = 3, mean ± SD, 2-tailed Student’s t test). ( B ) Representative images showing immunostaining of phosphorylated myosin light chain 2 <t>(MYL2),</t> fascin1 (FSCN1), SUN2, and GM130 in the indicated cells. DAPI counterstaining in all images. ( C ) Representative images of filamentous actin (F-actin) staining examine the cytoskeleton of calvarial cells isolated from Lmna +/+ (WT) and Lmna L648R/L648R ( Lmna L648R ) mice. Graphs indicate quantitation of the average intensity of F-actin in 5 independent experiments ( P < 0.003, n = 3, mean ± SEM, 2-tailed Student’s t test). Scale bars: 50 μm ( A and C ), 20 μm ( B ).
Gene Exp Myl2 Hs00166405 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 89/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myl2/Gene+Exp%2E+MYL2%2C+Hs00166405_m1/pmc12604142-99-26--1
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mouse anti myl2  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology mouse anti myl2
( A ) Representative images of Lamin A/C staining examine nuclear morphology in the cultured SuSCs (left panels) and calvarial cells (2 right panels). Graphs show quantitation of the average percentage of calvarial cells containing abnormal nuclear shape in 3 independent experiments ( P < 0.001 or 0.0005, n = 3, mean ± SD, 2-tailed Student’s t test). ( B ) Representative images showing immunostaining of phosphorylated myosin light chain 2 <t>(MYL2),</t> fascin1 (FSCN1), SUN2, and GM130 in the indicated cells. DAPI counterstaining in all images. ( C ) Representative images of filamentous actin (F-actin) staining examine the cytoskeleton of calvarial cells isolated from Lmna +/+ (WT) and Lmna L648R/L648R ( Lmna L648R ) mice. Graphs indicate quantitation of the average intensity of F-actin in 5 independent experiments ( P < 0.003, n = 3, mean ± SEM, 2-tailed Student’s t test). Scale bars: 50 μm ( A and C ), 20 μm ( B ).
Mouse Anti Myl2, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myl2/MYL2+Antibody/pmc12564145-156-95-97
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mouse anti myl2 - by Bioz Stars, 2026-09
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phospho ser18 mlc2  (OriGene)
90
OriGene phospho ser18 mlc2
( A ) Representative images of Lamin A/C staining examine nuclear morphology in the cultured SuSCs (left panels) and calvarial cells (2 right panels). Graphs show quantitation of the average percentage of calvarial cells containing abnormal nuclear shape in 3 independent experiments ( P < 0.001 or 0.0005, n = 3, mean ± SD, 2-tailed Student’s t test). ( B ) Representative images showing immunostaining of phosphorylated myosin light chain 2 <t>(MYL2),</t> fascin1 (FSCN1), SUN2, and GM130 in the indicated cells. DAPI counterstaining in all images. ( C ) Representative images of filamentous actin (F-actin) staining examine the cytoskeleton of calvarial cells isolated from Lmna +/+ (WT) and Lmna L648R/L648R ( Lmna L648R ) mice. Graphs indicate quantitation of the average intensity of F-actin in 5 independent experiments ( P < 0.003, n = 3, mean ± SEM, 2-tailed Student’s t test). Scale bars: 50 μm ( A and C ), 20 μm ( B ).
Phospho Ser18 Mlc2, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myl2/Myosin+Light+Chain+2+(MYL2)+(pSer19)+Rabbit+Polyclonal+Antibody/pm41086913-98-59-62
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phosphoserine 19 myl2  (Rockland Immunochemicals)
92
Rockland Immunochemicals phosphoserine 19 myl2
( A ) Representative images of Lamin A/C staining examine nuclear morphology in the cultured SuSCs (left panels) and calvarial cells (2 right panels). Graphs show quantitation of the average percentage of calvarial cells containing abnormal nuclear shape in 3 independent experiments ( P < 0.001 or 0.0005, n = 3, mean ± SD, 2-tailed Student’s t test). ( B ) Representative images showing immunostaining of phosphorylated myosin light chain 2 <t>(MYL2),</t> fascin1 (FSCN1), SUN2, and GM130 in the indicated cells. DAPI counterstaining in all images. ( C ) Representative images of filamentous actin (F-actin) staining examine the cytoskeleton of calvarial cells isolated from Lmna +/+ (WT) and Lmna L648R/L648R ( Lmna L648R ) mice. Graphs indicate quantitation of the average intensity of F-actin in 5 independent experiments ( P < 0.003, n = 3, mean ± SEM, 2-tailed Student’s t test). Scale bars: 50 μm ( A and C ), 20 μm ( B ).
Phosphoserine 19 Myl2, supplied by Rockland Immunochemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


PCA of the three cardiac stromal populations and HL-1 cardiomyocytes. ( A ) PCA of the four cell populations shown: CTs ( n = 55), CDCs ( n = 41), and CFs ( n = 29) at passage 3, as well as HL-1 cardiomyocytes ( n = 13). Both CTs and CDCs represent 3 biological replicates. Dim.1 separates the cardiac stromal populations, whereas Dim.2 shows a distinct separation between cardiac stromal and myocyte populations. Gene loadings contributing to each Dim suggest that a small subset of genes explains the cross-group variability captured by Dim.1 and Dim.2. Tcf21 is associated with CTs (emphasised by the blue circle), whereas Tbx5 is associated with CDCs and CFs (emphasised by the brown circle). The separation between cardiac stromal and myocyte populations is reflected by clustering of core cardiac and cardiomyocyte genes ( Nkx2-5 , Wif1 , Nppa , Myl2 , and Myh6 ), which are emphasised by the pink circle. ( B ) PCA of the three cardiac stromal populations alone: CTs ( n = 28), CDCs ( n = 41), and CFs ( n = 27). Both CTs and CDCs represent 3 biological replicates. Gene loadings contributing to each Dim show that Tcf21 is associated with CTs, whereas Tbx5 is associated with CDCs and CFs.

Journal: Cells

Article Title: Transcriptomic Analysis of Adult Mouse Cardiac Stromal Cells Using Single-Cell qRT-PCR

doi: 10.3390/cells15040384

Figure Lengend Snippet: PCA of the three cardiac stromal populations and HL-1 cardiomyocytes. ( A ) PCA of the four cell populations shown: CTs ( n = 55), CDCs ( n = 41), and CFs ( n = 29) at passage 3, as well as HL-1 cardiomyocytes ( n = 13). Both CTs and CDCs represent 3 biological replicates. Dim.1 separates the cardiac stromal populations, whereas Dim.2 shows a distinct separation between cardiac stromal and myocyte populations. Gene loadings contributing to each Dim suggest that a small subset of genes explains the cross-group variability captured by Dim.1 and Dim.2. Tcf21 is associated with CTs (emphasised by the blue circle), whereas Tbx5 is associated with CDCs and CFs (emphasised by the brown circle). The separation between cardiac stromal and myocyte populations is reflected by clustering of core cardiac and cardiomyocyte genes ( Nkx2-5 , Wif1 , Nppa , Myl2 , and Myh6 ), which are emphasised by the pink circle. ( B ) PCA of the three cardiac stromal populations alone: CTs ( n = 28), CDCs ( n = 41), and CFs ( n = 27). Both CTs and CDCs represent 3 biological replicates. Gene loadings contributing to each Dim show that Tcf21 is associated with CTs, whereas Tbx5 is associated with CDCs and CFs.

Article Snippet: Myl2 , Mm00440384_m1 , Plp1 , Mm01297210_m1.

Techniques:

( A ) Representative images of Lamin A/C staining examine nuclear morphology in the cultured SuSCs (left panels) and calvarial cells (2 right panels). Graphs show quantitation of the average percentage of calvarial cells containing abnormal nuclear shape in 3 independent experiments ( P < 0.001 or 0.0005, n = 3, mean ± SD, 2-tailed Student’s t test). ( B ) Representative images showing immunostaining of phosphorylated myosin light chain 2 (MYL2), fascin1 (FSCN1), SUN2, and GM130 in the indicated cells. DAPI counterstaining in all images. ( C ) Representative images of filamentous actin (F-actin) staining examine the cytoskeleton of calvarial cells isolated from Lmna +/+ (WT) and Lmna L648R/L648R ( Lmna L648R ) mice. Graphs indicate quantitation of the average intensity of F-actin in 5 independent experiments ( P < 0.003, n = 3, mean ± SEM, 2-tailed Student’s t test). Scale bars: 50 μm ( A and C ), 20 μm ( B ).

Journal: JCI Insight

Article Title: Stem cell–associated osteogenic deficiency causes craniofacial deformities with progeroid accumulation of prelamin A

doi: 10.1172/jci.insight.196932

Figure Lengend Snippet: ( A ) Representative images of Lamin A/C staining examine nuclear morphology in the cultured SuSCs (left panels) and calvarial cells (2 right panels). Graphs show quantitation of the average percentage of calvarial cells containing abnormal nuclear shape in 3 independent experiments ( P < 0.001 or 0.0005, n = 3, mean ± SD, 2-tailed Student’s t test). ( B ) Representative images showing immunostaining of phosphorylated myosin light chain 2 (MYL2), fascin1 (FSCN1), SUN2, and GM130 in the indicated cells. DAPI counterstaining in all images. ( C ) Representative images of filamentous actin (F-actin) staining examine the cytoskeleton of calvarial cells isolated from Lmna +/+ (WT) and Lmna L648R/L648R ( Lmna L648R ) mice. Graphs indicate quantitation of the average intensity of F-actin in 5 independent experiments ( P < 0.003, n = 3, mean ± SEM, 2-tailed Student’s t test). Scale bars: 50 μm ( A and C ), 20 μm ( B ).

Article Snippet: Mouse monoclonal antibodies against Bmpr1a (NBP2-37421, 1:75, Novus Biologicals), fascin1 (SC-21743, 1:100, Santa Cruz), and Alexa Fluor 568 phalloidin (A12380, 1:400, Invitrogen); rabbit polyclonal antibodies Osx (ab22552, 1:800, Abcam), OCN (23418-1-AP, 1:50, Proteintech), Gli1 (NBP1-78259, 1:100, Novus Biologicals), Myl2 (3671, 1:100, Cell Signaling Technology), and GM130 (2296, 1:200, Cell Signaling Technology); rabbit monoclonal antibodies lamin A/C (MA5-35284, 1:200, Invitrogen) and SUN2(EPR6557, 1:100, Abcam); anti-rabbit secondary antibody (BA-1000, 1:200, Vector laboratories); and anti-mouse IgG secondary antibodies (PK-2200, 1:250, Vector laboratories), were used in the immunostaining studies.

Techniques: Staining, Cell Culture, Quantitation Assay, Immunostaining, Isolation