Journal: Circulation. Genomic and Precision Medicine

Article Title: Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy

doi: 10.1161/CIRCGEN.123.004369

Figure Lengend Snippet: Comprehensive overview of alterations in energy metabolism and lipid-handling pathways in patients with hypertrophic cardiomyopathy (HCM) vs nonfailing (NF) donors integrating metabolomics, lipidomics, and proteomics data. Metabolomic, lipidomic, and proteomic data were integrated to provide an overview of changes in major energy metabolism and lipid-handling pathways. Metabolites and lipids are indicated by objects with a dark fill and white text; proteins are indicated by objects with a light fill and black text. Blue, orange, and gray indicate lower, higher, and unchanged abundances in HCM vs NF donors, respectively. Created with BioRender.com .

Article Snippet: Processed metabolomics, lipidomics, and proteomics data are furthermore available as a Supplemental Material ( Multi-Omics Data Sets ).

Techniques:

Journal: Circulation. Genomic and Precision Medicine

Article Title: Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy

doi: 10.1161/CIRCGEN.123.004369

Figure Lengend Snippet: Limited agreement among studies into metabolomic and lipidomic changes in tissue of patients with hypertrophic cardiomyopathy (HCM) compared with nonfailing (NF) donor tissue. A , Pie chart visualizing agreement in metabolite findings in HCM vs NF donor cardiac tissue samples; 114 metabolites were detected in at least 2 studies. Of these metabolites, 92 displayed inconsistent outcomes in HCM vs NF donor tissue. B , Table displaying consistency in lipidomic findings in HCM vs NF donor tissue. Blue and orange indicate consistently lowered and elevated levels, respectively, in HCM vs NF donors. *Derived from both metabolomics and lipidomics.

Article Snippet: Processed metabolomics, lipidomics, and proteomics data are furthermore available as a Supplemental Material ( Multi-Omics Data Sets ).

Techniques: Derivative Assay

Journal: Journal of Neurochemistry

Article Title: Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers

doi: 10.1111/jnc.15719

Figure Lengend Snippet: Seventeen predicted lipid species in the AD multi‐omics data sets with a VIP score >1 in the ABCA7‐KO cortical lipidome

Article Snippet: Conditional cell‐type enrichment was performed on a combined AD‐metabolic multi‐omics data set to investigate enrichment relationships.

Techniques: Biomarker Discovery