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Sensitivity, Specificity, and Realistic Adherence Assumptions for Each Screening Strategy

Journal: JAMA Network Open

Article Title: Cost-Effectiveness of Noninvasive Colorectal Cancer Screening in Community Clinics

doi: 10.1001/jamanetworkopen.2024.54938

Figure Lengend Snippet: Sensitivity, Specificity, and Realistic Adherence Assumptions for Each Screening Strategy

Article Snippet: We simulated 4 screening strategies: no screening, annual FIT, biennial FIT, , triennial mt-sDNA test, and a triennial blood test (Shield; Guardant Health).

Techniques:

Projected CRC Outcomes for Screening Programs Based on a FIT, mt-sDNA Test, or a Blood-Based Test <xref ref-type= a " width="100%" height="100%">

Journal: JAMA Network Open

Article Title: Cost-Effectiveness of Noninvasive Colorectal Cancer Screening in Community Clinics

doi: 10.1001/jamanetworkopen.2024.54938

Figure Lengend Snippet: Projected CRC Outcomes for Screening Programs Based on a FIT, mt-sDNA Test, or a Blood-Based Test a

Article Snippet: We simulated 4 screening strategies: no screening, annual FIT, biennial FIT, , triennial mt-sDNA test, and a triennial blood test (Shield; Guardant Health).

Techniques:

Projected Cost-Effectiveness Outcomes <xref ref-type= a " width="100%" height="100%">

Journal: JAMA Network Open

Article Title: Cost-Effectiveness of Noninvasive Colorectal Cancer Screening in Community Clinics

doi: 10.1001/jamanetworkopen.2024.54938

Figure Lengend Snippet: Projected Cost-Effectiveness Outcomes a

Article Snippet: We simulated 4 screening strategies: no screening, annual FIT, biennial FIT, , triennial mt-sDNA test, and a triennial blood test (Shield; Guardant Health).

Techniques:

ROC curves and AUC for (A) CRC a (sensitivity category 1) and (B) any advanced neoplasia b (CRC or APLs, sensitivity categories 1–2) vs 1-specificity for the absence of advanced neoplasia (categories 3–6) for the first-generation and next-generation mt-sDNA tests in the DeeP-C test set. APL, advanced precancerous lesion; AUC, area under the curve; CRC, colorectal cancer; mt-sDNA, multitarget stool DNA; ROC, receiver operating characteristic. a Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.03 (95% CI, 0.004–0.05); P = .02. b Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.04 (95% CI, 0.02–0.06); P < .0001.

Journal: Gastro Hep Advances

Article Title: Algorithm Development and Early Performance Evaluation of a Next-Generation Multitarget Stool DNA Screening Test for Colorectal Cancer

doi: 10.1016/j.gastha.2024.05.002

Figure Lengend Snippet: ROC curves and AUC for (A) CRC a (sensitivity category 1) and (B) any advanced neoplasia b (CRC or APLs, sensitivity categories 1–2) vs 1-specificity for the absence of advanced neoplasia (categories 3–6) for the first-generation and next-generation mt-sDNA tests in the DeeP-C test set. APL, advanced precancerous lesion; AUC, area under the curve; CRC, colorectal cancer; mt-sDNA, multitarget stool DNA; ROC, receiver operating characteristic. a Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.03 (95% CI, 0.004–0.05); P = .02. b Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.04 (95% CI, 0.02–0.06); P < .0001.

Article Snippet: APL, advanced precancerous lesion; AUC, area under the curve; CRC, colorectal cancer; mt-sDNA, multitarget stool DNA; ROC, receiver operating characteristic. a Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.03 (95% CI, 0.004–0.05); P = .02. b Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.04 (95% CI, 0.02–0.06); P < .0001.

Techniques:

Performance of the Next-Generation mt-sDNA Test Compared With Historical Performance of the First-Generation mt-sDNA Test in the DeeP-C Test Set

Journal: Gastro Hep Advances

Article Title: Algorithm Development and Early Performance Evaluation of a Next-Generation Multitarget Stool DNA Screening Test for Colorectal Cancer

doi: 10.1016/j.gastha.2024.05.002

Figure Lengend Snippet: Performance of the Next-Generation mt-sDNA Test Compared With Historical Performance of the First-Generation mt-sDNA Test in the DeeP-C Test Set

Article Snippet: APL, advanced precancerous lesion; AUC, area under the curve; CRC, colorectal cancer; mt-sDNA, multitarget stool DNA; ROC, receiver operating characteristic. a Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.03 (95% CI, 0.004–0.05); P = .02. b Difference in area under the ROC curve for the next-generation mt-sDNA test vs the first-generation mt-sDNA test: 0.04 (95% CI, 0.02–0.06); P < .0001.

Techniques: