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compounds of microsource discovery's mssp library  (MicroSource Discovery Systems)

 
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    MicroSource Discovery Systems compounds of microsource discovery's mssp library
    Compounds Of Microsource Discovery's Mssp Library, supplied by MicroSource Discovery Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mssp+library/microsource+spectrum/us08664237-56-9-9
    Average 90 stars, based on 1 article reviews
    compounds of microsource discovery's mssp library - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    High Throughput Screening Assay:

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
    Article Snippet: was from Trevigen (Gaithersburg, MD, USA), while anti-rabbit IgG secondary antibody and HRP-conjugated anti-β-actin antibody were from Sigma-Aldrich. .. MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA). .. Johns Hopkins Drug Library (JHDL) was supplied by one of the authors, Prof. Jun Liu.

    Fluorescence:

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
    Article Snippet: was from Trevigen (Gaithersburg, MD, USA), while anti-rabbit IgG secondary antibody and HRP-conjugated anti-β-actin antibody were from Sigma-Aldrich. .. MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA). .. Johns Hopkins Drug Library (JHDL) was supplied by one of the authors, Prof. Jun Liu.

    Biomarker Discovery:

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
    Article Snippet: was from Trevigen (Gaithersburg, MD, USA), while anti-rabbit IgG secondary antibody and HRP-conjugated anti-β-actin antibody were from Sigma-Aldrich. .. MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA). .. Johns Hopkins Drug Library (JHDL) was supplied by one of the authors, Prof. Jun Liu.

    Blocking Assay:

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
    Article Snippet: was from Trevigen (Gaithersburg, MD, USA), while anti-rabbit IgG secondary antibody and HRP-conjugated anti-β-actin antibody were from Sigma-Aldrich. .. MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA). .. Johns Hopkins Drug Library (JHDL) was supplied by one of the authors, Prof. Jun Liu.

    Polymer:

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
    Article Snippet: was from Trevigen (Gaithersburg, MD, USA), while anti-rabbit IgG secondary antibody and HRP-conjugated anti-β-actin antibody were from Sigma-Aldrich. .. MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA). .. Johns Hopkins Drug Library (JHDL) was supplied by one of the authors, Prof. Jun Liu.

    Cell Culture:

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
    Article Snippet: was from Trevigen (Gaithersburg, MD, USA), while anti-rabbit IgG secondary antibody and HRP-conjugated anti-β-actin antibody were from Sigma-Aldrich. .. MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA). .. Johns Hopkins Drug Library (JHDL) was supplied by one of the authors, Prof. Jun Liu.



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    Flow chart for the screening project. Assay was developed and optimized in HeLa cells and then employed for high-throughput screen of two chemical libraries: the <t>MSSP</t> <t>Library</t> and the JHDL. AB (fluorescence-based) or CTG (luminescence-based) was used to quantify cell viability. Compounds showing toxicity were rescreened at 2 and 5 μM while those with marginal protective effects were rescreened at 20 μM. The 10 hits from the primary screen were rescreened for validation. One compound was confirmed as true hit. A number of small molecules belonging to the same class as this compound or similar classes were then selected and screened, resulting in one more hit that was then validated. Dose–response data were obtained for the two hits; they were proven to block the synthesis and accumulation of toxic PAR polymer and were also neuroprotective in cell culture. They are now to be investigated for their ability to afford neuroprotection in animal models of neuronal death.
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    Flow chart for the screening project. Assay was developed and optimized in HeLa cells and then employed for high-throughput screen of two chemical libraries: the MSSP Library and the JHDL. AB (fluorescence-based) or CTG (luminescence-based) was used to quantify cell viability. Compounds showing toxicity were rescreened at 2 and 5 μM while those with marginal protective effects were rescreened at 20 μM. The 10 hits from the primary screen were rescreened for validation. One compound was confirmed as true hit. A number of small molecules belonging to the same class as this compound or similar classes were then selected and screened, resulting in one more hit that was then validated. Dose–response data were obtained for the two hits; they were proven to block the synthesis and accumulation of toxic PAR polymer and were also neuroprotective in cell culture. They are now to be investigated for their ability to afford neuroprotection in animal models of neuronal death.

    Journal: British Journal of Pharmacology

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos

    doi: 10.1111/bph.12201

    Figure Lengend Snippet: Flow chart for the screening project. Assay was developed and optimized in HeLa cells and then employed for high-throughput screen of two chemical libraries: the MSSP Library and the JHDL. AB (fluorescence-based) or CTG (luminescence-based) was used to quantify cell viability. Compounds showing toxicity were rescreened at 2 and 5 μM while those with marginal protective effects were rescreened at 20 μM. The 10 hits from the primary screen were rescreened for validation. One compound was confirmed as true hit. A number of small molecules belonging to the same class as this compound or similar classes were then selected and screened, resulting in one more hit that was then validated. Dose–response data were obtained for the two hits; they were proven to block the synthesis and accumulation of toxic PAR polymer and were also neuroprotective in cell culture. They are now to be investigated for their ability to afford neuroprotection in animal models of neuronal death.

    Article Snippet: MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA).

    Techniques: High Throughput Screening Assay, Fluorescence, Biomarker Discovery, Blocking Assay, Polymer, Cell Culture

    Flow chart for the screening project. Assay was developed and optimized in HeLa cells and then employed for high-throughput screen of two chemical libraries: the MSSP Library and the JHDL. AB (fluorescence-based) or CTG (luminescence-based) was used to quantify cell viability. Compounds showing toxicity were rescreened at 2 and 5 μM while those with marginal protective effects were rescreened at 20 μM. The 10 hits from the primary screen were rescreened for validation. One compound was confirmed as true hit. A number of small molecules belonging to the same class as this compound or similar classes were then selected and screened, resulting in one more hit that was then validated. Dose–response data were obtained for the two hits; they were proven to block the synthesis and accumulation of toxic PAR polymer and were also neuroprotective in cell culture. They are now to be investigated for their ability to afford neuroprotection in animal models of neuronal death.

    Journal: British Journal of Pharmacology

    Article Title: Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos

    doi: 10.1111/bph.12201

    Figure Lengend Snippet: Flow chart for the screening project. Assay was developed and optimized in HeLa cells and then employed for high-throughput screen of two chemical libraries: the MSSP Library and the JHDL. AB (fluorescence-based) or CTG (luminescence-based) was used to quantify cell viability. Compounds showing toxicity were rescreened at 2 and 5 μM while those with marginal protective effects were rescreened at 20 μM. The 10 hits from the primary screen were rescreened for validation. One compound was confirmed as true hit. A number of small molecules belonging to the same class as this compound or similar classes were then selected and screened, resulting in one more hit that was then validated. Dose–response data were obtained for the two hits; they were proven to block the synthesis and accumulation of toxic PAR polymer and were also neuroprotective in cell culture. They are now to be investigated for their ability to afford neuroprotection in animal models of neuronal death.

    Article Snippet: MSSP Library (2 mM) was purchased from the Johns Hopkins ChemCORE Facility (10 mM stock was originally purchased from MicroSource Discovery Inc., Groton, CT, USA).

    Techniques: High Throughput Screening Assay, Fluorescence, Biomarker Discovery, Blocking Assay, Polymer, Cell Culture