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mrtx1257  (MedChemExpress)
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MedChemExpress mrtx1257
N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), <t>MRTX1257</t> (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.
Mrtx1257, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mrtx1257 cayman  (MedChemExpress)
93
MedChemExpress mrtx1257 cayman
N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), <t>MRTX1257</t> (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.
Mrtx1257 Cayman, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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internal standard mrtx  (MedChemExpress)
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MedChemExpress internal standard mrtx
N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), <t>MRTX1257</t> (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.
Internal Standard Mrtx, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mrtx 1257  (MedChemExpress)
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MedChemExpress mrtx 1257
N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), <t>MRTX1257</t> (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.
Mrtx 1257, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mrtx 1257  (Danaher Inc)
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Danaher Inc mrtx 1257
N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), <t>MRTX1257</t> (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.
Mrtx 1257, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mrtx  (MedChemExpress)
93
MedChemExpress mrtx
N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), <t>MRTX1257</t> (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.
Mrtx, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mrtx-1257 (is; purity: 98%; fig. 1b)  (Angene International Limited)
90
Angene International Limited mrtx-1257 (is; purity: 98%; fig. 1b)
N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), <t>MRTX1257</t> (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.
Mrtx 1257 (Is; Purity: 98%; Fig. 1b), supplied by Angene International Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), MRTX1257 (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.

Journal: Cell Reports Medicine

Article Title: Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells

doi: 10.1016/j.xcrm.2025.102446

Figure Lengend Snippet: N17350 broadly kills cancer cells while preserving immune cells (A and B) Various cancer cell lines and primary cancer cells from OvCa patients were treated with increasing doses of N17350 for 24 h, and the EC50 was determined (n = 2–6/dose). (A) Representative killing curves for OvCa patient cancer cells (left), lung cancer cells with distinct KRAS variants (middle), and other tumor types (right). (B) Summary of EC50 values (left) and cancer-cell-type origin (right). (C) Representative tumor growth curve for NCI-H358 and NCI-H2122 tumors (non-small cell lung cancer) treated with N17350 (400 μg/100 mm 3 , intra-tumoral), MRTX1257 (100 mg/kg, oral, daily), or carboplatin (100 mg/kg, intraperitoneal, days 0 and 7); n = 5 mice/group. (D) N17350 efficacy 72 h after a single intra-tumoral injection across various xenograft models; n = 5–7 mice/group. (E) Cancer and non-cancer cells were isolated from OvCa patients, treated with N17350 (500 nM), doxorubicin (10 μM), or oxaliplatin (100 μM) for 24 h, and cell viability was assessed; n = 2–3/patient, n = 31–39 patients/group. (F) Representative N17350 killing curve (left) and eXEC50 values (right) for cancer cells and CD45 + immune cells isolated from the same tumor of OvCa patients ( n = 3/dose across patients). EC50 values for immune cells were assigned as >10,000 nM, as the maximal tested dose failed to achieve a response plateau, precluding accurate curve fitting. ∗ p < 0.05, two-way ANOVA (C and E), Student’s t test: unpaired (D) and paired (F). Results are mean ± SEM. Arrows indicate N17350 treatment. All replicates are independent biological replicates.

Article Snippet: MRTX1257 , MedChemExpress , Cat#2206736-04-9 Lot#49910.

Techniques: Preserving, Injection, Isolation