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mpg v6 3  (Azenta)
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Azenta mpg v6 3
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Mpg V6 3, supplied by Azenta, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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propylene glycol mpg  (Merck & Co)
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Merck & Co propylene glycol mpg
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Propylene Glycol Mpg, supplied by Merck & Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/propylene glycol mpg/product/Merck & Co
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mpg buffer  (Thermo Fisher)
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Thermo Fisher mpg buffer
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Mpg Buffer, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti mpg  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology anti mpg
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Anti Mpg, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ft acr pcdna3 1 plasmid  (Addgene inc)
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Addgene inc ft acr pcdna3 1 plasmid
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Ft Acr Pcdna3 1 Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ft acr pcdna3 1 plasmid - by Bioz Stars, 2026-05
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ans acr pcdna3 1 plasmid  (Addgene inc)
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Addgene inc ans acr pcdna3 1 plasmid
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Ans Acr Pcdna3 1 Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ans acr pcdna3 1 plasmid/product/Addgene inc
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ans acr pcdna3 1 plasmid - by Bioz Stars, 2026-05
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pcdna3 1 backbone recombinant dna reagent nlccr pcdna3 1 plasmid  (Addgene inc)
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Addgene inc pcdna3 1 backbone recombinant dna reagent nlccr pcdna3 1 plasmid
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Pcdna3 1 Backbone Recombinant Dna Reagent Nlccr Pcdna3 1 Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pcdna3 1 backbone recombinant dna reagent nlccr pcdna3 1 plasmid - by Bioz Stars, 2026-05
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pcdna3 1 backbone recombinant dna reagent ftacr pcdna3 1 plasmid  (Addgene inc)
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Addgene inc pcdna3 1 backbone recombinant dna reagent ftacr pcdna3 1 plasmid
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Pcdna3 1 Backbone Recombinant Dna Reagent Ftacr Pcdna3 1 Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pcdna3 1 backbone recombinant dna reagent ftacr pcdna3 1 plasmid/product/Addgene inc
Average 93 stars, based on 1 article reviews
pcdna3 1 backbone recombinant dna reagent ftacr pcdna3 1 plasmid - by Bioz Stars, 2026-05
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ge/siemens combination of vendor and mpgs  (Siemens AG)
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Siemens AG ge/siemens combination of vendor and mpgs
Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG <t>v6.3,</t> derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).
Ge/Siemens Combination Of Vendor And Mpgs, supplied by Siemens AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG v6.3, derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).

Journal: Nucleic Acids Research

Article Title: Triple base editor catalyzes saturation mutation of adenine, cytidine, and guanine

doi: 10.1093/nar/gkaf1423

Figure Lengend Snippet: Design and screening of triple base editors (ACG-BEs). ( a ) The process of ACG-BEs catalyzes three types of base substrates (A, C, and G) to generate DNA sequence diversity. Adenosine deaminase refers to evolved Escherichia coli adenosine deaminase mutants (TadA-8e, T AD AC-3.1, T AD AC-3.155, and TadA-dual); nCas9, Cas9 D10A; MPG v6.3, derived from evolved N-methylpurine DNA glycosylase. ( b ) Schematics of the constructs for ACG-BEs. bNLS, bipartite nuclear localization signals; T AD AC-3.1, T AD AC-3.155, and TadA-dual, derived from evolved E. coli adenosine deaminase; nCas9, Cas9 D10A; MPG v3, and MPG v6.3, derived from evolved N-methylpurine DNA glycosylase; linkers are also shown. ( c ) Base-editing outcomes of ACG-BEs at the endogenous target PLS3-AS1 -sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments). ( d ) Allele table for PLS3-AS1 -sg1 in HEK293T cells after ACG-BE7 transfection. The target site allele is boxed in a gray line. The percentile and sequencing read of each allele at one representative of three independent experiments are listed on the right. ( e ) The allele base editing efficiency of ACG-BEs across the protospacer at the endogenous target PLS3-AS1- sg1 in HEK293T cells. Data are means ± SD ( n = 3 independent experiments).

Article Snippet: Human codon-optimized TadA-dual, T AD A-3.1, T AD A-3.155, MPGv3, and MPG v6.3 were synthesized by Genewiz (Suzhou, China).

Techniques: Sequencing, Derivative Assay, Construct, Transfection