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( A to D ) Activated CD8 + T cells were expanded for 16 hours in the presence IL-2 +/- <t>molidustat</t> (MOL; 60 μM). 4-1BB (A), CD81 (B), GITR (C), or OX40 (D) mRNA was analyzed by RT-qPCR (mean +/- SEM, n = 3). * P < 0.05, **** P < 0.0001 versus vehicle (two-tailed Student’s t test).
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( A to D ) Activated CD8 + T cells were expanded for 16 hours in the presence IL-2 +/- molidustat (MOL; 60 μM). 4-1BB (A), CD81 (B), GITR (C), or OX40 (D) mRNA was analyzed by RT-qPCR (mean +/- SEM, n = 3). * P < 0.05, **** P < 0.0001 versus vehicle (two-tailed Student’s t test).

Journal: Science Advances

Article Title: Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy

doi: 10.1126/sciadv.adq2366

Figure Lengend Snippet: ( A to D ) Activated CD8 + T cells were expanded for 16 hours in the presence IL-2 +/- molidustat (MOL; 60 μM). 4-1BB (A), CD81 (B), GITR (C), or OX40 (D) mRNA was analyzed by RT-qPCR (mean +/- SEM, n = 3). * P < 0.05, **** P < 0.0001 versus vehicle (two-tailed Student’s t test).

Article Snippet: The cells were activated for 48 hours and then expansion medium containing recombinant mouse IL-2 (20 ng/ml; BioLegend, catalog no. 575404) was added to the cells as well as DMSO (Corning Lifescience Cellgro, catalog no. MT 25-950-CQC) or one of the following hydroxylase inhibitors (dissolved in DMSO): DMOG (Cayman Chemical, catalog no. 71210), molidustat (Selleck Chemicals, catalog no. S8138), daprodustat (Selleck Chemicals, catalog no. S8171), or roxadustat (Selleck Chemicals, catalog no. S1007).

Techniques: Quantitative RT-PCR, Two Tailed Test

After 5 days of expansion with IL-2 +/- molidustat (MOL; 60 μM), the expression of 4-1BB ( A ), CD81 ( B ), GITR ( C ), or OX40 ( D ) costimulatory receptor on the surface of activated CD8 + T cells was measured by flow cytometry.

Journal: Science Advances

Article Title: Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy

doi: 10.1126/sciadv.adq2366

Figure Lengend Snippet: After 5 days of expansion with IL-2 +/- molidustat (MOL; 60 μM), the expression of 4-1BB ( A ), CD81 ( B ), GITR ( C ), or OX40 ( D ) costimulatory receptor on the surface of activated CD8 + T cells was measured by flow cytometry.

Article Snippet: The cells were activated for 48 hours and then expansion medium containing recombinant mouse IL-2 (20 ng/ml; BioLegend, catalog no. 575404) was added to the cells as well as DMSO (Corning Lifescience Cellgro, catalog no. MT 25-950-CQC) or one of the following hydroxylase inhibitors (dissolved in DMSO): DMOG (Cayman Chemical, catalog no. 71210), molidustat (Selleck Chemicals, catalog no. S8138), daprodustat (Selleck Chemicals, catalog no. S8171), or roxadustat (Selleck Chemicals, catalog no. S1007).

Techniques: Expressing, Flow Cytometry