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OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale <t>PBPK</t> model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.
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OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale <t>PBPK</t> model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.
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OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale <t>PBPK</t> model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.
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OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale <t>PBPK</t> model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.
Model Report For Ec' Simulations, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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comsol model report  (COMSOL Inc)
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OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale <t>PBPK</t> model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.
Comsol Model Report, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale PBPK model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: Open Systems Pharmacology Community Conference ( OSP ‐ CC ) Proceedings 2025

doi: 10.1002/psp4.70217

Figure Lengend Snippet: OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale PBPK model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.

Article Snippet: Session 4: Submission, lifecycle & approval , An automated reporting workflows automating PBPK model documentation and regulatory reporting , Ghazal Montaseri (Boehringer Ingelheim) Felix Mil (ESQlabs).

Techniques: Transferring, Modification