Review





Similar Products

mitomycin c mmc treated h2122 cells  (Thermo Fisher)
97
Thermo Fisher mitomycin c mmc treated h2122 cells
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Mitomycin C Mmc Treated H2122 Cells, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mitomycin c mmc treated h2122 cells/product/Thermo Fisher
Average 97 stars, based on 1 article reviews
mitomycin c mmc treated h2122 cells - by Bioz Stars, 2026-02
97/100 stars
  Buy from Supplier
mmc  (MedChemExpress)
96
MedChemExpress mmc
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Mmc, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mmc/product/MedChemExpress
Average 96 stars, based on 1 article reviews
mmc - by Bioz Stars, 2026-02
96/100 stars
  Buy from Supplier
mmc  (Merocel Corp)
90
Merocel Corp mmc
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Mmc, supplied by Merocel Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mmc/product/Merocel Corp
Average 90 stars, based on 1 article reviews
mmc - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
microcrystalline cellulose (mmc)  (Sinopharm ltd)
90
Sinopharm ltd microcrystalline cellulose (mmc)
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Microcrystalline Cellulose (Mmc), supplied by Sinopharm ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/microcrystalline cellulose (mmc)/product/Sinopharm ltd
Average 90 stars, based on 1 article reviews
microcrystalline cellulose (mmc) - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
mitomycin c mmc  (STEMCELL Technologies Inc)
90
STEMCELL Technologies Inc mitomycin c mmc
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Mitomycin C Mmc, supplied by STEMCELL Technologies Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mitomycin c mmc/product/STEMCELL Technologies Inc
Average 90 stars, based on 1 article reviews
mitomycin c mmc - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
mitomycin c inj mmc  (Bukwang Pharmaceutical)
90
Bukwang Pharmaceutical mitomycin c inj mmc
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Mitomycin C Inj Mmc, supplied by Bukwang Pharmaceutical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mitomycin c inj mmc/product/Bukwang Pharmaceutical
Average 90 stars, based on 1 article reviews
mitomycin c inj mmc - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
mmc  (Bukwang Pharmaceutical)
90
Bukwang Pharmaceutical mmc
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Mmc, supplied by Bukwang Pharmaceutical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mmc/product/Bukwang Pharmaceutical
Average 90 stars, based on 1 article reviews
mmc - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
mmc  (Cayman Chemical)
90
Cayman Chemical mmc
DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL <t>H2122</t> cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.
Mmc, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mmc/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
mmc - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier

Image Search Results


DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL H2122 cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.

Journal: Cancer Research Communications

Article Title: Dipeptidyl Peptidase 4 Restoration Facilitates Antitumor Immunity in KRAS-LKB1–Mutant Lung Cancer

doi: 10.1158/2767-9764.CRC-25-0199

Figure Lengend Snippet: DPP4 is a potential therapeutic target in KRAS -mutant cells via NK cell recruitment. A, Immunoblotting of the indicated proteins in KL H2122 cells transduced with the indicated vectors. B, DPP4 activity induced by DPP4-Glo in KL H2122 cells transduced with the indicated vectors ( n = 3). C, GSEA showing significantly differentially expressed pathways. GSEA Gene Ontology Biological Process (GO BP) category upregulation in DPP4-reconstituted H2122 cells relative to luciferase (LUC)-reconstituted H2122 cells. D, GSEA of NK cell activation involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. E, ELISA for human granzyme B in conditioned medium (CM) derived from H2122 cells cocultured with NK-92 cells ( n = 3). F, Schematic of an immune cell migration assay using a three-dimensional microfluidic device with tumor spheroids embedded in a central collagen-filled channel and immune cells cocultured in a side channel. G, Representative images of NK-92 cell migration toward H2122 or DPP4-overexpressing H2122 cells (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. H, Representative images of NK-92 cell migration in KP H2009 cells treated with and without sitagliptin (left). Immune infiltration into the peritumor region was quantified using ImageJ software (right). Scale bars, 500 μm. I, ELISA for human granzyme B in CM derived from H2009 cells treated with and without sitagliptin and cocultured with NK-92 cells ( n = 3). J, Evaluation of H2122-specific CD8 + T-cell migration toward H2122 or DPP4-overexpressing H2122 cells. Immune infiltration into the peritumor region was quantified using ImageJ software. K, ELISA for human granzyme B in CM derived from H2122 cells cocultured with H2122-specific CD8 + T cells ( n = 3). L, GSEA of T-cell migration involved in the immune response signature in H2122 cells transduced with DPP4 or LUC. P values were calculated using an unpaired two-tailed Student's t test. *, P < 0.05; ***, P < 0.001.

Article Snippet: To generate H2122-specific T cells, PBMCs were cocultured with mitomycin C (MMC)–treated H2122 cells in AIM-V medium (Invitrogen) supplemented with 3% human male AB serum (Innovative Research), 10 IU/mL IL2, and 10 ng/mL IL15.

Techniques: Mutagenesis, Western Blot, Transduction, Activity Assay, Luciferase, Activation Assay, Enzyme-linked Immunosorbent Assay, Derivative Assay, Cell Migration Assay, Migration, Software, Two Tailed Test