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ml 385  (MedChemExpress)
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MedChemExpress ml 385
Ml 385, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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ml385  (Tocris)
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Tocris ml385
<t>ML385</t> significantly inhibits Nrf2 transcriptional activity. Colon gene expression of nqo1 ( a ) in 3 month-old, and ( b ) 6-month-old mice from the control and ML385 groups. Colon gene expression of nfe2l2 ( c ) in 3 month-old, and, ( d ) 6-month-old mice from the control and ML385 groups. Eef2 —a reference gene. Dots represent a single observation. N = 4–6 per group. * p < 0.05, ** p < 0.01, Mann–Whitney U or Kolmogorov–Smirnov test.
Ml385, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
ml385 - by Bioz Stars, 2026-02
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nrf2-specific inhibitor ml-385  (Cayman Chemical)
90
Cayman Chemical nrf2-specific inhibitor ml-385
<t>ML385</t> significantly inhibits Nrf2 transcriptional activity. Colon gene expression of nqo1 ( a ) in 3 month-old, and ( b ) 6-month-old mice from the control and ML385 groups. Colon gene expression of nfe2l2 ( c ) in 3 month-old, and, ( d ) 6-month-old mice from the control and ML385 groups. Eef2 —a reference gene. Dots represent a single observation. N = 4–6 per group. * p < 0.05, ** p < 0.01, Mann–Whitney U or Kolmogorov–Smirnov test.
Nrf2 Specific Inhibitor Ml 385, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/nrf2-specific inhibitor ml-385/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
nrf2-specific inhibitor ml-385 - by Bioz Stars, 2026-02
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wmi met ml 385 group  (MedChemExpress)
96
MedChemExpress wmi met ml 385 group
<t>ML385</t> significantly inhibits Nrf2 transcriptional activity. Colon gene expression of nqo1 ( a ) in 3 month-old, and ( b ) 6-month-old mice from the control and ML385 groups. Colon gene expression of nfe2l2 ( c ) in 3 month-old, and, ( d ) 6-month-old mice from the control and ML385 groups. Eef2 —a reference gene. Dots represent a single observation. N = 4–6 per group. * p < 0.05, ** p < 0.01, Mann–Whitney U or Kolmogorov–Smirnov test.
Wmi Met Ml 385 Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/wmi met ml 385 group/product/MedChemExpress
Average 96 stars, based on 1 article reviews
wmi met ml 385 group - by Bioz Stars, 2026-02
96/100 stars
  Buy from Supplier

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ML385 significantly inhibits Nrf2 transcriptional activity. Colon gene expression of nqo1 ( a ) in 3 month-old, and ( b ) 6-month-old mice from the control and ML385 groups. Colon gene expression of nfe2l2 ( c ) in 3 month-old, and, ( d ) 6-month-old mice from the control and ML385 groups. Eef2 —a reference gene. Dots represent a single observation. N = 4–6 per group. * p < 0.05, ** p < 0.01, Mann–Whitney U or Kolmogorov–Smirnov test.

Journal: International Journal of Molecular Sciences

Article Title: Chemical Inhibition of NRF2 Transcriptional Activity Influences Colon Function and Oestrogen Receptor Expression in Mice at Different Ages

doi: 10.3390/ijms252413647

Figure Lengend Snippet: ML385 significantly inhibits Nrf2 transcriptional activity. Colon gene expression of nqo1 ( a ) in 3 month-old, and ( b ) 6-month-old mice from the control and ML385 groups. Colon gene expression of nfe2l2 ( c ) in 3 month-old, and, ( d ) 6-month-old mice from the control and ML385 groups. Eef2 —a reference gene. Dots represent a single observation. N = 4–6 per group. * p < 0.05, ** p < 0.01, Mann–Whitney U or Kolmogorov–Smirnov test.

Article Snippet: To block NRF2 transcriptional activity, the mice were administered 100 µL of ML385 (30 mg/kg/day; Tocris Bioscience, Bristol, UK) or 1% DMSO (Sigma-Aldrich, Dortmund, Germany) via intraperitoneal injection for 7 days prior to the isolation of colon tissue.

Techniques: Activity Assay, Expressing, Control, MANN-WHITNEY

ML385 influences colon contractility in older mice. Colonic bead expulsion assay. Female control and ML385-treated mice, 3- and 6-month-old. N = 4–6 per group. Dots represent a single observation. * p < 0.05, ANOVA followed by Tukey’s test.

Journal: International Journal of Molecular Sciences

Article Title: Chemical Inhibition of NRF2 Transcriptional Activity Influences Colon Function and Oestrogen Receptor Expression in Mice at Different Ages

doi: 10.3390/ijms252413647

Figure Lengend Snippet: ML385 influences colon contractility in older mice. Colonic bead expulsion assay. Female control and ML385-treated mice, 3- and 6-month-old. N = 4–6 per group. Dots represent a single observation. * p < 0.05, ANOVA followed by Tukey’s test.

Article Snippet: To block NRF2 transcriptional activity, the mice were administered 100 µL of ML385 (30 mg/kg/day; Tocris Bioscience, Bristol, UK) or 1% DMSO (Sigma-Aldrich, Dortmund, Germany) via intraperitoneal injection for 7 days prior to the isolation of colon tissue.

Techniques: Control

Inhibition of NRF22 transcriptional activity influences goblet cell number in young mice. ( a ) colon morphology (H&E staining), magnification 400×, ( b ) microscopic scoring, ( c ) goblet cells scoring, ( d ) colon morphology (PAS staining) magnification 400×, ( e ) goblet cells PAS scoring. Female control and ML385-treated mice, 3- and 6-month-old. N = 4–6 per group. Dots represent a single observation. * p < 0.05, ANOVA followed by Tukey’s test, scale bar 50 µm.

Journal: International Journal of Molecular Sciences

Article Title: Chemical Inhibition of NRF2 Transcriptional Activity Influences Colon Function and Oestrogen Receptor Expression in Mice at Different Ages

doi: 10.3390/ijms252413647

Figure Lengend Snippet: Inhibition of NRF22 transcriptional activity influences goblet cell number in young mice. ( a ) colon morphology (H&E staining), magnification 400×, ( b ) microscopic scoring, ( c ) goblet cells scoring, ( d ) colon morphology (PAS staining) magnification 400×, ( e ) goblet cells PAS scoring. Female control and ML385-treated mice, 3- and 6-month-old. N = 4–6 per group. Dots represent a single observation. * p < 0.05, ANOVA followed by Tukey’s test, scale bar 50 µm.

Article Snippet: To block NRF2 transcriptional activity, the mice were administered 100 µL of ML385 (30 mg/kg/day; Tocris Bioscience, Bristol, UK) or 1% DMSO (Sigma-Aldrich, Dortmund, Germany) via intraperitoneal injection for 7 days prior to the isolation of colon tissue.

Techniques: Inhibition, Activity Assay, Staining, Control

The influence of ML385 on serum oestrogen level. Female control and ML385-treated mice, 3 and 6-month-old. N = 4–6 per group. Dots represent a single observation. p values were calculated using an ANOVA followed by Tukey’s test.

Journal: International Journal of Molecular Sciences

Article Title: Chemical Inhibition of NRF2 Transcriptional Activity Influences Colon Function and Oestrogen Receptor Expression in Mice at Different Ages

doi: 10.3390/ijms252413647

Figure Lengend Snippet: The influence of ML385 on serum oestrogen level. Female control and ML385-treated mice, 3 and 6-month-old. N = 4–6 per group. Dots represent a single observation. p values were calculated using an ANOVA followed by Tukey’s test.

Article Snippet: To block NRF2 transcriptional activity, the mice were administered 100 µL of ML385 (30 mg/kg/day; Tocris Bioscience, Bristol, UK) or 1% DMSO (Sigma-Aldrich, Dortmund, Germany) via intraperitoneal injection for 7 days prior to the isolation of colon tissue.

Techniques: Control

Effect of ML385 on oestrogen receptor localisation in the colon. Panels ( A , B ) show oestrogen receptor alpha (ERα, red), DiOC6 (green), and nuclei (blue); panels ( C , D ) show oestrogen receptor beta (ERβ, red), DiOC6 (green) and nuclei (blue); and panels ( E , F ) show GPR30 (red), DiOC6 (green), and nuclei (blue) in 3-month-old and 6-month-old mice treated with either vehicle or ML385. DiOC6-3,3′-Dihexyloxacarbocyanine Iodide cell membrane dye. Images were captured at 600× magnification, with a scale bar of 25 μm.

Journal: International Journal of Molecular Sciences

Article Title: Chemical Inhibition of NRF2 Transcriptional Activity Influences Colon Function and Oestrogen Receptor Expression in Mice at Different Ages

doi: 10.3390/ijms252413647

Figure Lengend Snippet: Effect of ML385 on oestrogen receptor localisation in the colon. Panels ( A , B ) show oestrogen receptor alpha (ERα, red), DiOC6 (green), and nuclei (blue); panels ( C , D ) show oestrogen receptor beta (ERβ, red), DiOC6 (green) and nuclei (blue); and panels ( E , F ) show GPR30 (red), DiOC6 (green), and nuclei (blue) in 3-month-old and 6-month-old mice treated with either vehicle or ML385. DiOC6-3,3′-Dihexyloxacarbocyanine Iodide cell membrane dye. Images were captured at 600× magnification, with a scale bar of 25 μm.

Article Snippet: To block NRF2 transcriptional activity, the mice were administered 100 µL of ML385 (30 mg/kg/day; Tocris Bioscience, Bristol, UK) or 1% DMSO (Sigma-Aldrich, Dortmund, Germany) via intraperitoneal injection for 7 days prior to the isolation of colon tissue.

Techniques: Membrane