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mk 801  (MedChemExpress)
95
MedChemExpress mk 801
DLT Ameliorates a broad range of schizophrenia-like behavioral deficits in <t>the</t> <t>MK-801</t> mouse model. ( A ) Schematic of the experimental design for the MK-801-induced schizophrenia (SCZ) model and desloratadine (DLT) treatment timeline. ( B ) Representative locomotor track plots from the open field test for control (Con), SCZ, and DLT-treated SCZ mice. ( C ) Quantification of total distance traveled, and percentage of time spent in the center zone during the open field test. ( D ) Representative heatmaps during Session 1 (sociability) and Session 2 (social novelty), illustrating interaction time in different zones of the apparatus. ( E ) Quantification of social behavior from the three-chamber test, including time spent in the interaction zone during the Session 1 (sociability) and Session 2 (social novelty), and interaction time. Grooming test for stereotypy, showing ( F ) total time and ( G ) frequency of grooming events. ( H ) PPI test of acoustic startle at different prepulse intensities (76, 79, and 85 dB) with a 120 dB startle pulse. ( I ) Escape latency over the 5-d training phase, showing impaired learning in the SCZ group that is improved by DLT. Quantification of ( J ) platform crosses, ( K ) latency to first cross the platform location, and ( L ) percentage of time spent in the target quadrant during the probe trial. All data are presented as mean ± SEM (n = 7–10 mice per group). Statistical significance was assessed using two-way ANOVA with repeated measures (for MWM training) or one-way ANOVA followed by Tukey’s post-hoc test (for all other panels). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. ns, not significant
Mk 801, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mk-801/Dizocilpine/pmc13294246-34-12-15
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mk 801 - by Bioz Stars, 2026-10
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mk 801  (Tocris)
94
Tocris mk 801
DLT Ameliorates a broad range of schizophrenia-like behavioral deficits in <t>the</t> <t>MK-801</t> mouse model. ( A ) Schematic of the experimental design for the MK-801-induced schizophrenia (SCZ) model and desloratadine (DLT) treatment timeline. ( B ) Representative locomotor track plots from the open field test for control (Con), SCZ, and DLT-treated SCZ mice. ( C ) Quantification of total distance traveled, and percentage of time spent in the center zone during the open field test. ( D ) Representative heatmaps during Session 1 (sociability) and Session 2 (social novelty), illustrating interaction time in different zones of the apparatus. ( E ) Quantification of social behavior from the three-chamber test, including time spent in the interaction zone during the Session 1 (sociability) and Session 2 (social novelty), and interaction time. Grooming test for stereotypy, showing ( F ) total time and ( G ) frequency of grooming events. ( H ) PPI test of acoustic startle at different prepulse intensities (76, 79, and 85 dB) with a 120 dB startle pulse. ( I ) Escape latency over the 5-d training phase, showing impaired learning in the SCZ group that is improved by DLT. Quantification of ( J ) platform crosses, ( K ) latency to first cross the platform location, and ( L ) percentage of time spent in the target quadrant during the probe trial. All data are presented as mean ± SEM (n = 7–10 mice per group). Statistical significance was assessed using two-way ANOVA with repeated measures (for MWM training) or one-way ANOVA followed by Tukey’s post-hoc test (for all other panels). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. ns, not significant
Mk 801, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mk-801/(%2B)-MK+801+maleate/pm41980665-105-50-51
Average 94 stars, based on 1 article reviews
mk 801 - by Bioz Stars, 2026-10
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lab n a mk 801 maleate tocris bioscience 0924 mpep hydrochloride bio techne 1212 ly 367385 tocris bioscience  (Tocris)
94
Tocris lab n a mk 801 maleate tocris bioscience 0924 mpep hydrochloride bio techne 1212 ly 367385 tocris bioscience
DLT Ameliorates a broad range of schizophrenia-like behavioral deficits in <t>the</t> <t>MK-801</t> mouse model. ( A ) Schematic of the experimental design for the MK-801-induced schizophrenia (SCZ) model and desloratadine (DLT) treatment timeline. ( B ) Representative locomotor track plots from the open field test for control (Con), SCZ, and DLT-treated SCZ mice. ( C ) Quantification of total distance traveled, and percentage of time spent in the center zone during the open field test. ( D ) Representative heatmaps during Session 1 (sociability) and Session 2 (social novelty), illustrating interaction time in different zones of the apparatus. ( E ) Quantification of social behavior from the three-chamber test, including time spent in the interaction zone during the Session 1 (sociability) and Session 2 (social novelty), and interaction time. Grooming test for stereotypy, showing ( F ) total time and ( G ) frequency of grooming events. ( H ) PPI test of acoustic startle at different prepulse intensities (76, 79, and 85 dB) with a 120 dB startle pulse. ( I ) Escape latency over the 5-d training phase, showing impaired learning in the SCZ group that is improved by DLT. Quantification of ( J ) platform crosses, ( K ) latency to first cross the platform location, and ( L ) percentage of time spent in the target quadrant during the probe trial. All data are presented as mean ± SEM (n = 7–10 mice per group). Statistical significance was assessed using two-way ANOVA with repeated measures (for MWM training) or one-way ANOVA followed by Tukey’s post-hoc test (for all other panels). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. ns, not significant
Lab N A Mk 801 Maleate Tocris Bioscience 0924 Mpep Hydrochloride Bio Techne 1212 Ly 367385 Tocris Bioscience, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mk-801/(-)-MK+801+maleate/pm41915835-215-118-125
Average 94 stars, based on 1 article reviews
lab n a mk 801 maleate tocris bioscience 0924 mpep hydrochloride bio techne 1212 ly 367385 tocris bioscience - by Bioz Stars, 2026-10
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mk 801  (Merck & Co)
86
Merck & Co mk 801
DLT Ameliorates a broad range of schizophrenia-like behavioral deficits in <t>the</t> <t>MK-801</t> mouse model. ( A ) Schematic of the experimental design for the MK-801-induced schizophrenia (SCZ) model and desloratadine (DLT) treatment timeline. ( B ) Representative locomotor track plots from the open field test for control (Con), SCZ, and DLT-treated SCZ mice. ( C ) Quantification of total distance traveled, and percentage of time spent in the center zone during the open field test. ( D ) Representative heatmaps during Session 1 (sociability) and Session 2 (social novelty), illustrating interaction time in different zones of the apparatus. ( E ) Quantification of social behavior from the three-chamber test, including time spent in the interaction zone during the Session 1 (sociability) and Session 2 (social novelty), and interaction time. Grooming test for stereotypy, showing ( F ) total time and ( G ) frequency of grooming events. ( H ) PPI test of acoustic startle at different prepulse intensities (76, 79, and 85 dB) with a 120 dB startle pulse. ( I ) Escape latency over the 5-d training phase, showing impaired learning in the SCZ group that is improved by DLT. Quantification of ( J ) platform crosses, ( K ) latency to first cross the platform location, and ( L ) percentage of time spent in the target quadrant during the probe trial. All data are presented as mean ± SEM (n = 7–10 mice per group). Statistical significance was assessed using two-way ANOVA with repeated measures (for MWM training) or one-way ANOVA followed by Tukey’s post-hoc test (for all other panels). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. ns, not significant
Mk 801, supplied by Merck & Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mk-801/801+mk/pm41916281-843-9-10
Average 86 stars, based on 1 article reviews
mk 801 - by Bioz Stars, 2026-10
86/100 stars
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DLT Ameliorates a broad range of schizophrenia-like behavioral deficits in the MK-801 mouse model. ( A ) Schematic of the experimental design for the MK-801-induced schizophrenia (SCZ) model and desloratadine (DLT) treatment timeline. ( B ) Representative locomotor track plots from the open field test for control (Con), SCZ, and DLT-treated SCZ mice. ( C ) Quantification of total distance traveled, and percentage of time spent in the center zone during the open field test. ( D ) Representative heatmaps during Session 1 (sociability) and Session 2 (social novelty), illustrating interaction time in different zones of the apparatus. ( E ) Quantification of social behavior from the three-chamber test, including time spent in the interaction zone during the Session 1 (sociability) and Session 2 (social novelty), and interaction time. Grooming test for stereotypy, showing ( F ) total time and ( G ) frequency of grooming events. ( H ) PPI test of acoustic startle at different prepulse intensities (76, 79, and 85 dB) with a 120 dB startle pulse. ( I ) Escape latency over the 5-d training phase, showing impaired learning in the SCZ group that is improved by DLT. Quantification of ( J ) platform crosses, ( K ) latency to first cross the platform location, and ( L ) percentage of time spent in the target quadrant during the probe trial. All data are presented as mean ± SEM (n = 7–10 mice per group). Statistical significance was assessed using two-way ANOVA with repeated measures (for MWM training) or one-way ANOVA followed by Tukey’s post-hoc test (for all other panels). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. ns, not significant

Journal: Molecular Neurobiology

Article Title: Desloratadine Rescues Schizophrenia-like Phenotypes by Inhibiting the Pathogenic 5-HT2AR-PI3K/AKT/mTOR Signaling Axis

doi: 10.1007/s12035-026-06027-z

Figure Lengend Snippet: DLT Ameliorates a broad range of schizophrenia-like behavioral deficits in the MK-801 mouse model. ( A ) Schematic of the experimental design for the MK-801-induced schizophrenia (SCZ) model and desloratadine (DLT) treatment timeline. ( B ) Representative locomotor track plots from the open field test for control (Con), SCZ, and DLT-treated SCZ mice. ( C ) Quantification of total distance traveled, and percentage of time spent in the center zone during the open field test. ( D ) Representative heatmaps during Session 1 (sociability) and Session 2 (social novelty), illustrating interaction time in different zones of the apparatus. ( E ) Quantification of social behavior from the three-chamber test, including time spent in the interaction zone during the Session 1 (sociability) and Session 2 (social novelty), and interaction time. Grooming test for stereotypy, showing ( F ) total time and ( G ) frequency of grooming events. ( H ) PPI test of acoustic startle at different prepulse intensities (76, 79, and 85 dB) with a 120 dB startle pulse. ( I ) Escape latency over the 5-d training phase, showing impaired learning in the SCZ group that is improved by DLT. Quantification of ( J ) platform crosses, ( K ) latency to first cross the platform location, and ( L ) percentage of time spent in the target quadrant during the probe trial. All data are presented as mean ± SEM (n = 7–10 mice per group). Statistical significance was assessed using two-way ANOVA with repeated measures (for MWM training) or one-way ANOVA followed by Tukey’s post-hoc test (for all other panels). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. ns, not significant

Article Snippet: The Schizophrenia (SCZ) model was established by daily intraperitoneal (i.p.) injections of MK-801 (2 mg/kg/day; MedChemExpress) for 6 consecutive days (Days 1–6).

Techniques: Control