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Example of a super-resolution ultrasound repeatability scan. Super-resolved maps of the breast tumour microvasculature are acquired at 4 imaging planes (horizontal, 90o, 45o clockwise and 45o counterclockwise at the tumour centre), repeated twice after a first and second contrast bolus. The brightness corresponds to the number of localisations per pixel. The white arrows show the positioning of the ultrasound probe. The white boxes highlight distinctive microvascular structures which are present after both boluses.

Journal: medRxiv

Article Title: In-Patient Repeatability and Sensitivity Study of Multi-Plane Super-Resolution Ultrasound in Breast Cancer

doi: 10.1101/2024.10.15.24315514

Figure Lengend Snippet: Example of a super-resolution ultrasound repeatability scan. Super-resolved maps of the breast tumour microvasculature are acquired at 4 imaging planes (horizontal, 90o, 45o clockwise and 45o counterclockwise at the tumour centre), repeated twice after a first and second contrast bolus. The brightness corresponds to the number of localisations per pixel. The white arrows show the positioning of the ultrasound probe. The white boxes highlight distinctive microvascular structures which are present after both boluses.

Article Snippet: Vessel diameter was calculated by first skeletonising the binary image of the microvascular structure (bwmorph, MATLAB, Image Processing Toolbox) to obtain the blood vessel centrelines.

Techniques: Imaging

Depiction of four examples of super-resolution ultrasound microvascular maps within the tumour and surrounding tissue, overlaid on the B-mode tissue image, both before, 2-weeks and 6-months after radiotherapy (RT). The brightness corresponds to the number of localisations per pixel. Within the participant cohort, baseline tumour microvascular structures exhibit significant heterogeneity, and post-treatment responses vary widely. a ) The baseline tumour has microvessels around the periphery but not within the core. There is a visible decrease in vascular density by 6-months post-RT. b) and c ) The baseline tumour has a dense microvasculature structure. There is a visible reduction in intra-tumoural blood vessels as early as 2-weeks post-RT. d ) The tumour exhibits a low degree of vascularity, and there is an increase in microvessels post-treatment.

Journal: medRxiv

Article Title: In-Patient Repeatability and Sensitivity Study of Multi-Plane Super-Resolution Ultrasound in Breast Cancer

doi: 10.1101/2024.10.15.24315514

Figure Lengend Snippet: Depiction of four examples of super-resolution ultrasound microvascular maps within the tumour and surrounding tissue, overlaid on the B-mode tissue image, both before, 2-weeks and 6-months after radiotherapy (RT). The brightness corresponds to the number of localisations per pixel. Within the participant cohort, baseline tumour microvascular structures exhibit significant heterogeneity, and post-treatment responses vary widely. a ) The baseline tumour has microvessels around the periphery but not within the core. There is a visible decrease in vascular density by 6-months post-RT. b) and c ) The baseline tumour has a dense microvasculature structure. There is a visible reduction in intra-tumoural blood vessels as early as 2-weeks post-RT. d ) The tumour exhibits a low degree of vascularity, and there is an increase in microvessels post-treatment.

Article Snippet: Vessel diameter was calculated by first skeletonising the binary image of the microvascular structure (bwmorph, MATLAB, Image Processing Toolbox) to obtain the blood vessel centrelines.

Techniques: